CAJ | 학술논문

目的：探讨血管内皮生长因子C（ VEGF-C）和肿瘤转移抑制基因（ nm23 H1）在宫颈增生性病变发生、发展过程中的表达及其临床意义。方法采用免疫组织化学法检测51例宫颈鳞状细胞癌组织中VEGF-C和nm23 H1的表达水平，以31例宫颈炎性、修复性增生组织，27例宫颈上皮内瘤变组织做对照，对结果进行分析。结果在宫颈炎性、修复性增生组织，宫颈上皮内瘤变及宫颈鳞状细胞癌组织中，VEGF-C的表达分别为3．2％、40．7％、72．5％，3组间比较有显著性差异（χ2＝37．702，P＜0．01）；nm23 H1的表达分别为100．0％、59．2％、33．3％，3组间比较有显著性差异（χ2＝35．349，P＜0．01）。在宫颈鳞癌组织中， VEGF-C和nm23 H1在伴有淋巴结转移的组织中阳性表达率为87．5％和16．7％；未伴淋巴结转移中阳性表达率为59．3％和48．1％。在宫颈增生性病变组织中，无论有无淋巴结转移，VEGF-C与nm23 H1阳性表达始终呈负相关（r＝-0．532，P＜0．05）。结论 VEGF-C和nm23 H1存在相关性，并在宫颈鳞癌的发生、发展、预后和转移方面发挥着重要作用，其可作为评价宫颈病变、推测预后的重要参考指标。
목적：탐토혈관내피생장인자C（ VEGF-C）화종류전이억제기인（ nm23 H1）재궁경증생성병변발생、발전과정중적표체급기림상의의。방법채용면역조직화학법검측51례궁경린상세포암조직중VEGF-C화nm23 H1적표체수평，이31례궁경염성、수복성증생조직，27례궁경상피내류변조직주대조，대결과진행분석。결과재궁경염성、수복성증생조직，궁경상피내류변급궁경린상세포암조직중，VEGF-C적표체분별위3．2％、40．7％、72．5％，3조간비교유현저성차이（χ2＝37．702，P＜0．01）；nm23 H1적표체분별위100．0％、59．2％、33．3％，3조간비교유현저성차이（χ2＝35．349，P＜0．01）。재궁경린암조직중， VEGF-C화nm23 H1재반유림파결전이적조직중양성표체솔위87．5％화16．7％；미반림파결전이중양성표체솔위59．3％화48．1％。재궁경증생성병변조직중，무론유무림파결전이，VEGF-C여nm23 H1양성표체시종정부상관（r＝-0．532，P＜0．05）。결론 VEGF-C화nm23 H1존재상관성，병재궁경린암적발생、발전、예후화전이방면발휘착중요작용，기가작위평개궁경병변、추측예후적중요삼고지표。
Objective To explore the expression and clinical significance of VEGF-C and nm23 H1 in the occurrence and development of cervical hyperplasia lesions .Methods Immunohistochemistry was used to test the expression of VEGF-C and nm23 H1 in 51 samples of cervical squamous cell carcinoma tissues .The control group included 31 samples of normal cervical , inflammatory or reparative hyperplasia tissues and 27 samples of cervical intraepithelial neoplasia tissues .The results were analyzed .Results In cervical inflammatory and reparative hyperplasia tissues , cervical intraepithelial neoplasia tissues and cervical squamous cell carcinoma tissues , the positive expression rate of VEGF-C was 3.2%, 40.7%and 72.5%, respectively.The difference among them was significant (χ2 =37.702, P<0.01).The expression of nm23 H1 was 100.0%, 59.2%and 33.3%, respectively, and there was significant difference (χ2 =35.349, P<0.01).The positive expression rate of VEGF-C and nm23 H1 were 87.5%and 16.7%, respectively in cervical carcinoma tissue with lymph node metastasis, and 59.3% and 48.1%, respectively in cervical carcinoma tissue without lymph node metastasis .VEGF-C expression was negatively correlated with nm 23 H1 in cervical hyperplasia lesions with or without lymph nodes metastasis (r=-0.532,P<0.05).Conclusion VEGF-C is correlated with nm23 H1, and they play an important role in the occurrence , development, prognosis and metastasis of cervical squamous cell carcinoma , which may be important reference indexes for evaluating severity and predicting prognosis of cervical lesions .