CAJ | 학술논문

目的：通过测定妊娠期高血压疾病患者血尿酸含量，预测妊娠期高血压疾病病情的发展、肾功能早期变化及妊娠结局。方法对130例妊娠期高血压疾病患者，测定血尿酸、肌酐、尿素氮含量及尿蛋白半定量检查，并选择同期正常妊娠孕晚期129例作为对照。结果轻度子痫前期组、重度子痫前期组、子痫组尿酸含量逐渐增加，差异具有统计学意义（ F＝3．706，P＜0．05）；肌酐和尿素氮在轻度子痫前期组、重度子痫前期组、子痫组有逐渐增加的趋势，但差异无统计学意义（肌酐F＝10．368，P＞0．05；尿素氮F＝4．115，P＞0．05）。各尿蛋白组间比较血尿酸含量差异无统计学意义（F＝4．192，P＞0．05）。不同血尿酸含量围生儿死亡率不同，随着血尿酸含量增高围生儿死亡率增加。结论血尿酸可以估计妊娠期高血压疾病病情的发展，也可作为妊娠期高血压疾病肾功能损害比较敏感指标，与围生儿结局密切相关。
목적：통과측정임신기고혈압질병환자혈뇨산함량，예측임신기고혈압질병병정적발전、신공능조기변화급임신결국。방법대130례임신기고혈압질병환자，측정혈뇨산、기항、뇨소담함량급뇨단백반정량검사，병선택동기정상임신잉만기129례작위대조。결과경도자간전기조、중도자간전기조、자간조뇨산함량축점증가，차이구유통계학의의（ F＝3．706，P＜0．05）；기항화뇨소담재경도자간전기조、중도자간전기조、자간조유축점증가적추세，단차이무통계학의의（기항F＝10．368，P＞0．05；뇨소담F＝4．115，P＞0．05）。각뇨단백조간비교혈뇨산함량차이무통계학의의（F＝4．192，P＞0．05）。불동혈뇨산함량위생인사망솔불동，수착혈뇨산함량증고위생인사망솔증가。결론혈뇨산가이고계임신기고혈압질병병정적발전，야가작위임신기고혈압질병신공능손해비교민감지표，여위생인결국밀절상관。
Objective To forecast the progression of hypertensive disorders complicating pregnancy (HDCP), early changes of kidney function and pregnancy outcomes by detecting the serum uric acid (UA) in patients with HDCP.Methods Serum UA, creatinine (Cr), blood urea nitrogen ( BUN) and proteinuria were examined in 130 patients with HDCP and in 129 normal late-pregnancy women .Results The level of UA increased with the progression of the disease , and the changes had statistical significance (F=3.706, P<0.05).Cr and BUN also increased with the progression of the disease , but the differences were not significant (Cr F=10.368,P>0.05; BUN F=4.115,P>0.05).UA was not significantly different in each proteinuria group (F=4.192,P>0.05).With the increasing of UA level, the perinatal mortality rate increased .Conclusion The clinical detection of serum UA level appears to be useful in forecasting the progression of HDCP .And it can be taken as one of sensitive indexes to examine the dysfunction of kidney .UA has close relationship with perinatal outcomes .