中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2014年
3期
445-447
,共3页
妊娠高血压疾病%同型半胱氨酸%血管内皮生长因子%评价指标
妊娠高血壓疾病%同型半胱氨痠%血管內皮生長因子%評價指標
임신고혈압질병%동형반광안산%혈관내피생장인자%평개지표
hypertensive disorders in pregnancy (HDP)%homocysteine (Hcy)%vascular endothelial growth factor (VEGF)%evaluating indicator
目的：探讨同型半胱氨酸（ Hcy）、血管内皮生长因子（ VEGF）与妊娠高血压疾病（ HDP）的关系及其临床意义。方法选取浙江省瑞安市人民医院2012年1月至2013年12月收治的800例HDP患者为研究对象，其中妊娠高血压375例，轻度子痫305例，重度子痫120例，另选取同期正常孕晚期妇女800例为对照组，分别采用循环酶法及酶类免疫法测定两组血清Hcy、VEGF水平。结果与对照组相比，HDP组孕妇Hcy水平较高，而VEGF水平较低，差异有统计学意义（ t值分别为4．265和5．426，均P＜0．05）。与妊娠高血压组、轻度子痫组相比，重度子痫组孕妇血清Hcy水平较高，差异具有统计学意义（ t值分别为34．575和15．855，均P＜0．05），而VEGF水平较低，差异具有统计学意义（t值分别为9．512和6．906，均P＜0．05）。与预后良好组相比，预后差组孕妇血清Hcy水平较高，VEGF水平较低，差异有统计学意义（t值分别为5．448和6．325，均P＜0．05）。结论Hcy、VEGF水平升高与HDP病情发生、进展及转归具有密切的关系，Hcy、VEGF可作为HDP患者预后的评价指标。
目的：探討同型半胱氨痠（ Hcy）、血管內皮生長因子（ VEGF）與妊娠高血壓疾病（ HDP）的關繫及其臨床意義。方法選取浙江省瑞安市人民醫院2012年1月至2013年12月收治的800例HDP患者為研究對象，其中妊娠高血壓375例，輕度子癇305例，重度子癇120例，另選取同期正常孕晚期婦女800例為對照組，分彆採用循環酶法及酶類免疫法測定兩組血清Hcy、VEGF水平。結果與對照組相比，HDP組孕婦Hcy水平較高，而VEGF水平較低，差異有統計學意義（ t值分彆為4．265和5．426，均P＜0．05）。與妊娠高血壓組、輕度子癇組相比，重度子癇組孕婦血清Hcy水平較高，差異具有統計學意義（ t值分彆為34．575和15．855，均P＜0．05），而VEGF水平較低，差異具有統計學意義（t值分彆為9．512和6．906，均P＜0．05）。與預後良好組相比，預後差組孕婦血清Hcy水平較高，VEGF水平較低，差異有統計學意義（t值分彆為5．448和6．325，均P＜0．05）。結論Hcy、VEGF水平升高與HDP病情髮生、進展及轉歸具有密切的關繫，Hcy、VEGF可作為HDP患者預後的評價指標。
목적：탐토동형반광안산（ Hcy）、혈관내피생장인자（ VEGF）여임신고혈압질병（ HDP）적관계급기림상의의。방법선취절강성서안시인민의원2012년1월지2013년12월수치적800례HDP환자위연구대상，기중임신고혈압375례，경도자간305례，중도자간120례，령선취동기정상잉만기부녀800례위대조조，분별채용순배매법급매류면역법측정량조혈청Hcy、VEGF수평。결과여대조조상비，HDP조잉부Hcy수평교고，이VEGF수평교저，차이유통계학의의（ t치분별위4．265화5．426，균P＜0．05）。여임신고혈압조、경도자간조상비，중도자간조잉부혈청Hcy수평교고，차이구유통계학의의（ t치분별위34．575화15．855，균P＜0．05），이VEGF수평교저，차이구유통계학의의（t치분별위9．512화6．906，균P＜0．05）。여예후량호조상비，예후차조잉부혈청Hcy수평교고，VEGF수평교저，차이유통계학의의（t치분별위5．448화6．325，균P＜0．05）。결론Hcy、VEGF수평승고여HDP병정발생、진전급전귀구유밀절적관계，Hcy、VEGF가작위HDP환자예후적평개지표。
Objective To investigate the clinical significance of homocysteine (Hcy) and vascular endothelial growth factor (VEGF) and their relationship with hypertensive disorders in pregnancy ( HDP).Methods From January 2012 to December 2013 800 cases of HDP (375 cases of HDP, 305 cases of mild preeclampsia and 120 cases of severe preeclampsia) were admitted in People’s Hospital of Ruian City, and they were selected in HDP group .Another 800 cases of normal pregnant women at third trimester were selected in control group . The serum levels of Hcy and VEGF of two groups were detected with Enzymatic Cycling Assays Method and enzyme immunoassay .Results Hcy level of the HDP group was higher than the control group , but VEGF level was lower .The differences between two groups were significant (t value was 4.265 and 5.426, respectively, both P<0.05).Hcy level of the severe preeclampsia group was significantly higher than that of the HDP group and mild preeclampsia group (t value was 34.575 and 15.855, respectively, both P<0.05), but VEGF level was significantly lower (t value was 9.512 and 6.906, respectively, both P<0.05).Compared with the patients with good prognosis, the patients with poor prognosis had higher Hcy level and lower VEGF level , and the differences were significant ( t value was 5.448 and 6.325, respectively, both P<0.05).Conclusion Increased level of Hcy and decreased level of VEGF are closely related with the occurrence , progression and prognosis of HDP .Hcy and VEGF can be considered as evaluating indicators for prognosis of HDP .
