中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2014年
3期
443-444,445
,共3页
子痫前期%血管内皮生长因子%可溶性血管内皮生长因子受体%变化
子癇前期%血管內皮生長因子%可溶性血管內皮生長因子受體%變化
자간전기%혈관내피생장인자%가용성혈관내피생장인자수체%변화
preeclampsia%vascular endothelial growth factor (VEGF)%soluble fms-like tyrosine kinase receptor 1(sFlt-1)%change
目的：探讨子痫前期患者血清中血管内皮生长因子（VEGF）及其可溶性血管内皮生长因子受体1（sFlt-1）的水平及意义。方法选择2011年8月至2012年3月子痫前期患者共60例（研究组），其中轻度子痫前期孕妇30例，重度子痫前期孕妇30例，以同期正常晚期妊娠孕妇30例作为对照组。采用酶联免疫吸附试验法测定两组患者血清VEGF及其sFlt-1水平。结果子痫前期组孕晚期及临产前VEGF水平显著低于正常对照组（t值分别为-160．762、22．690，均P＜0．001），而sFlt-1水平显著高于正常对照组（t值分别为18．647、47．782，均P＜0．001）。轻度子痫前期组孕晚期及临产前VEGF水平显著高于重度子痫前期组（t值分别为4．869、4．626，均P＜0．05），而sFlt-1水平显著低于重度子痫前期组（t值分别为-3．59、-3．681，均P＜0．05）。两组产后1周VEGF和sFlt-1水平比较无显著性差异（t值分别为3．061、1．760，均P＞0．05）。结论子痫前期患者血清中sFlt-1水平于孕晚期及临产前较正常孕妇明显增高，而VEGF水平降低，提示VEGF、sFlt-1可作为诊断子痫前期的指标之一。
目的：探討子癇前期患者血清中血管內皮生長因子（VEGF）及其可溶性血管內皮生長因子受體1（sFlt-1）的水平及意義。方法選擇2011年8月至2012年3月子癇前期患者共60例（研究組），其中輕度子癇前期孕婦30例，重度子癇前期孕婦30例，以同期正常晚期妊娠孕婦30例作為對照組。採用酶聯免疫吸附試驗法測定兩組患者血清VEGF及其sFlt-1水平。結果子癇前期組孕晚期及臨產前VEGF水平顯著低于正常對照組（t值分彆為-160．762、22．690，均P＜0．001），而sFlt-1水平顯著高于正常對照組（t值分彆為18．647、47．782，均P＜0．001）。輕度子癇前期組孕晚期及臨產前VEGF水平顯著高于重度子癇前期組（t值分彆為4．869、4．626，均P＜0．05），而sFlt-1水平顯著低于重度子癇前期組（t值分彆為-3．59、-3．681，均P＜0．05）。兩組產後1週VEGF和sFlt-1水平比較無顯著性差異（t值分彆為3．061、1．760，均P＞0．05）。結論子癇前期患者血清中sFlt-1水平于孕晚期及臨產前較正常孕婦明顯增高，而VEGF水平降低，提示VEGF、sFlt-1可作為診斷子癇前期的指標之一。
목적：탐토자간전기환자혈청중혈관내피생장인자（VEGF）급기가용성혈관내피생장인자수체1（sFlt-1）적수평급의의。방법선택2011년8월지2012년3월자간전기환자공60례（연구조），기중경도자간전기잉부30례，중도자간전기잉부30례，이동기정상만기임신잉부30례작위대조조。채용매련면역흡부시험법측정량조환자혈청VEGF급기sFlt-1수평。결과자간전기조잉만기급임산전VEGF수평현저저우정상대조조（t치분별위-160．762、22．690，균P＜0．001），이sFlt-1수평현저고우정상대조조（t치분별위18．647、47．782，균P＜0．001）。경도자간전기조잉만기급임산전VEGF수평현저고우중도자간전기조（t치분별위4．869、4．626，균P＜0．05），이sFlt-1수평현저저우중도자간전기조（t치분별위-3．59、-3．681，균P＜0．05）。량조산후1주VEGF화sFlt-1수평비교무현저성차이（t치분별위3．061、1．760，균P＞0．05）。결론자간전기환자혈청중sFlt-1수평우잉만기급임산전교정상잉부명현증고，이VEGF수평강저，제시VEGF、sFlt-1가작위진단자간전기적지표지일。
Objective To investigate the serum levels and significance of vascular endothelial growth factor ( VEGF ) and its receptor soluble fms-like tyrosine kinase receptor 1 ( sFlt-1 ) in pregnant women with preeclampsia .Methods Totally 60 pregnant women with preeclampsia were selected in study group during the period of August 2011 to March 2012, including 30 cases with mild preeclampsia and 30 with severe preeclampsia .Another 30 normal women in late pregnancy were selected in control group .The levels of VEGF and sFlt-1 in two groups were detected by enzyme-linked immunosorbent assay (ELISA).Results The serum levels of VEGF in preeclampsia group at late pregnancy and postpartum were significantly lower than those in control group (t value was -160.762 and 22.690, respectively, both P<0.001), but the serum levels of sFlt-1 were significantly higher than those in control group ( t value was 18.647 and 47.782, respectively, both P<0.001).The serum levels of VEGF of mild preeclampsia group at late pregnancy and postpartum were significantly higher than those in severe preeclampsia group (t value was 4.869 and 4.626, respectively, both P<0.05).However, the serum levels of sFlt-1 of mild preeclampsia group were significantly lower than those of severe preeclampsia group ( t value was -3.59 and -3.681, respectively, both P<0.05).There was no significant difference in the levels of VEGF and sFlt-1 one week after delivery between two groups (t value was 3.061 and 1.760, respectively, both P>0.05).Conclusion The level of sFlt-1 in serum of preeclampsia patients at late pregnant stage is significantly higher than normal pregnant women , whereas the VEGF level goes down .VEGF as well as sFlt-1 can be used as the indicators for diagnosing preeclampsia .
