CAJ | 학술논문

目的：评估临床症状和生化指标对妊娠期肝内胆汁淤积症（ ICP）患者发生早产的预测价值。方法回顾性分析2008年4月至2013年2月就诊于广东省阳江市人民医院的60例ICP患者。用多元回归分析法寻找早产的预测指标。结果分娩的平均时间是38．1±1．7周，未出现死产婴儿。其中8例患者（13．3％）出现早产。与足月分娩相比，早产分娩者的总空腹血清胆汁酸水平更高（t＝2．46，P＜0．05）。多元回归分析发现，早发性瘙痒症状（OR＝1．71，95％CI：1．24～2．79，P＜0．05）和血清胆汁酸（OR＝2．23，95％CI：1．23～3．43，P＜0．05）是早产的独立预测指标。结论早发瘙痒症状和高水平血清胆汁酸是ICP患者发生早产的预测指标，并可用于界定具有不良婴幼儿结局的风险。
목적：평고림상증상화생화지표대임신기간내담즙어적증（ ICP）환자발생조산적예측개치。방법회고성분석2008년4월지2013년2월취진우광동성양강시인민의원적60례ICP환자。용다원회귀분석법심조조산적예측지표。결과분면적평균시간시38．1±1．7주，미출현사산영인。기중8례환자（13．3％）출현조산。여족월분면상비，조산분면자적총공복혈청담즙산수평경고（t＝2．46，P＜0．05）。다원회귀분석발현，조발성소양증상（OR＝1．71，95％CI：1．24～2．79，P＜0．05）화혈청담즙산（OR＝2．23，95％CI：1．23～3．43，P＜0．05）시조산적독립예측지표。결론조발소양증상화고수평혈청담즙산시ICP환자발생조산적예측지표，병가용우계정구유불량영유인결국적풍험。
Objective To evaluate the predictive value of clinical symptoms and biochemical parameters for prematurity in patients with intrahepatic cholestasis of pregnancy ( ICP) .Methods Sixty symptomatic patients with ICP visiting Yangjiang People ’ s Hospital during the period of April 2008 to February 2013 were included in this retrospective analysis .Predictors of premature delivery were disclosed by multivariate logistic regression analysis .Results Mean time of delivery was 38.1 ±1.7 week.No stillbirths occurred.Premature delivery was observed in 8(13.3%) patients.Total fasting serum bile acids of patients with premature delivery were higher when compared to those with term delivery (t=2.46,P<0.05).Multivariate logistic regression analysis revealed that early onset of pruritus (OR=1.71,95%CI:1.24-2.79,P<0.05) and serum bile acid (OR=2.23,95%CI:1.23-3.43,P<0.05) were independent predictors of premature delivery . Conclusion Early onset of pruritus and high level of serum bile acids predict premature delivery in ICP patients , and they can be borrowed to define a subgroup of patients at risk for poor neonatal outcomes .