CAJ | 학술논문

细菌性阴道病（bacterial vaginosis，BV）可增加女性患盆腔炎性疾病的风险，增加对性传播疾病的易感性及导致不良妊娠等后果。 BV的发病机制尚不清楚，其产生及复发的致病因素亦十分复杂。综述BV在微生物学及病理生理学方面的基本特征，描述了阴道微生态、产过氧化氢乳杆菌的缺失及导致BV相关致病菌的聚集等现象。讨论了细菌生物膜，尤其阴道加德纳菌生物膜在阴道上皮的黏附，不能有效地被免疫系统清除或完全被抗生素灭活，导致BV治疗后仍有慢性、持续性感染的状况。同时进一步对临床常用的BV治疗方案及针对生物膜特异性治疗的研究进展进行了总结，从而增加对BV的认识。
세균성음도병（bacterial vaginosis，BV）가증가녀성환분강염성질병적풍험，증가대성전파질병적역감성급도치불량임신등후과。 BV적발병궤제상불청초，기산생급복발적치병인소역십분복잡。종술BV재미생물학급병리생이학방면적기본특정，묘술료음도미생태、산과양화경유간균적결실급도치BV상관치병균적취집등현상。토론료세균생물막，우기음도가덕납균생물막재음도상피적점부，불능유효지피면역계통청제혹완전피항생소멸활，도치BV치료후잉유만성、지속성감염적상황。동시진일보대림상상용적BV치료방안급침대생물막특이성치료적연구진전진행료총결，종이증가대BV적인식。
Bacterial vaginosis (BV) can increase susceptibility of women to pelvic inflammatory disease,adverse pregnancy outcome and the risk of acquiring sexually transmitted diseases. Because of the factors causing BV and recurrent BV are complex,its etiology or pathogenesis still remains elusive. This review summarizes the microbiology and pathophysiology aspects of BV to enhance understanding of the vaginal microbiota ,which is characterized by the depletion of hydrogen peroxide-producing lactobacilli species and aggregation of bacterial vaginosis-associated bacteria (BVAB). Bacterial biofilm,formed by Gardnerella vaginalis in particular colonizes and adheres on the vaginal epithelium ,can′t be completely eradicated by host immune system or antibiotics,contributing to the chronic and recalcitrant infection. Further outlines on the current clinical therapy and the need to cater to specific biofilm eradication treatment to minimize its recurrence.