CAJ | 학술논문

妊娠期糖尿病（GDM）易造成子痫前期、羊水过多、巨大儿等多种并发症。目前在妊娠中晚期检测血糖筛查GDM，确诊患者接受治疗的时间短，母婴健康存在严重隐患。代谢组学（metabolomics）是一种定量考察生命系统受内外界刺激或基因修饰后的代谢应答规律的学科。将代谢组学的方法应用于GDM研究，有望实现GDM的早期诊断，理解GDM的致病机制，对GDM的防治和母婴预后都有重要的意义。综述代谢组学方法在GDM及相关疾病研究中的应用。
임신기당뇨병（GDM）역조성자간전기、양수과다、거대인등다충병발증。목전재임신중만기검측혈당사사GDM，학진환자접수치료적시간단，모영건강존재엄중은환。대사조학（metabolomics）시일충정량고찰생명계통수내외계자격혹기인수식후적대사응답규률적학과。장대사조학적방법응용우GDM연구，유망실현GDM적조기진단，리해GDM적치병궤제，대GDM적방치화모영예후도유중요적의의。종술대사조학방법재GDM급상관질병연구중적응용。
Gestational diabetes mellitus (GDM) easily lead to some complications,such as preeclampsia, polyhydramnios,macrosomia,and so on. The traditional diagnostic protocols for GDM mainly rely on detecting elevated glucose levels in blood,often late in the second trimester. Therefore the treatment time for the patients is not enough and the serious risk to maternal and child health raise. Metabolomics is an approach that investigates the metabolic responses of living systems to internal or external stimuli or genetic modification. The application of metabolomics to GDM research will help to interpret the pathogenesis of GDM. In addition,it can also provide the theoretical and experimental support for prevention and treatment of GDM as well as the prognosis of mothers and their infants. The characteristics of the common detection methods and the metabolomics studies of GDM were analyzed and compared in detail in this paper ,and the metabolomic studies in GDM was further reviewed.