CAJ | 학술논문

目的：运用Meta分析研究GNB3基因C825T位点多态性与勃起功能障碍的相关性。方法检索Pubmed、Medline、中国期刊网全文数据库（CNKI）、万方数据库和维普中文科技期刊库，按照纳入标准纳入文献，对文献进行资料提取后，运用STATA 12.0软件进行Meta分析。结果共纳入4篇研究，包括969例ED患者和795例对照。采用共显性模型进行Meta分析，结果显示CC基因型较TT基因型与勃起功能障碍发病无显著关联（OR=0.639，95%CI：0.386-1.059，P =0.083）；对不同人群进行亚组分析提示亚组人群CC基因型较TT基因型勃起功能障碍患病风险增加；欧洲人群GNB3基因C825T位点基因多态性与勃起功能障碍无明显关联（CC vs TT， OR=1.043，95%CI：0.602-1.810，P=0.88； CT vs TT，OR=0.989，95%CI：0.568-1.723，P=0.97）。结论亚洲人群GNB3基因CC基因型为勃起功能障碍的危险因素，而在欧洲人群中关联尚不明确。
목적：운용Meta분석연구GNB3기인C825T위점다태성여발기공능장애적상관성。방법검색Pubmed、Medline、중국기간망전문수거고（CNKI）、만방수거고화유보중문과기기간고，안조납입표준납입문헌，대문헌진행자료제취후，운용STATA 12.0연건진행Meta분석。결과공납입4편연구，포괄969례ED환자화795례대조。채용공현성모형진행Meta분석，결과현시CC기인형교TT기인형여발기공능장애발병무현저관련（OR=0.639，95%CI：0.386-1.059，P =0.083）；대불동인군진행아조분석제시아조인군CC기인형교TT기인형발기공능장애환병풍험증가；구주인군GNB3기인C825T위점기인다태성여발기공능장애무명현관련（CC vs TT， OR=1.043，95%CI：0.602-1.810，P=0.88； CT vs TT，OR=0.989，95%CI：0.568-1.723，P=0.97）。결론아주인군GNB3기인CC기인형위발기공능장애적위험인소，이재구주인군중관련상불명학。
Objective To investigate the association of GNB3 C825T polymorphism with erectile dysfunction. Methods The related literatures were extracted from the database of PubMed, Medline, CNKI, VIP and Wanfang according to the inclusion criteria. A meta-analysis was done using STATA 12.0 software. Results All of 969 patients and 795 controls in the extracted four published studies were analyzed by codominant genetic model. The results showed that GNB3 C825T polymorphism had no significant association with the risk of erectile dysfunction in the general population(OR=0.639, 95%CI: 0.386-1.059, P=0.083); Subgroup analysis indicated that CC genotype was significantly associated with erectile dysfunction in the Asian population(OR=0.431, 95%CI:0.290-0.642, P =0.00). However, there was no significant association in the European population(CC vs TT, OR=1.043, 95%CI: 0.602-1.810, P=0.88; CT vs TT, OR=0.989, 95%CI:0.568-1.723,P=0.97). Conclusion The CC genotype is a risk factor of erectile dysfunction in the Asian population, but not in the European population.