CAJ | 학술논문

目的：探讨雌激素受体β（ER-β）在老年骨质疏松小鼠股骨骨折修复中的影响。方法采用高选择性 ER-β受体拮抗剂（PHTPP）阻断 ER-β受体的老年骨质疏松小鼠股骨骨折模型作为实验组，未使用拮抗剂的老年骨质疏松小鼠股骨骨折模型作为对照组，在不同时间点采用放射学分析（术后0、1、2、3、4、5和6周）、骨痂血管新生的微焦点CT分析（术后1、2周）及骨痂生物力学测试（术后4、6周）观察2组骨折愈合情况。结果在不同时间点，实验组与对照组相比，ER-β阻断组的血管生成，成骨和机械性能方面都明显占优势，2组比较差异具有统计学意义（P＜0．05）。结论阻断 ER-β受体能明显提高早期血管形成、中期的软骨内骨化和晚期的机械力学性能等骨折修复能力。
목적：탐토자격소수체β（ER-β）재노년골질소송소서고골골절수복중적영향。방법채용고선택성 ER-β수체길항제（PHTPP）조단 ER-β수체적노년골질소송소서고골골절모형작위실험조，미사용길항제적노년골질소송소서고골골절모형작위대조조，재불동시간점채용방사학분석（술후0、1、2、3、4、5화6주）、골가혈관신생적미초점CT분석（술후1、2주）급골가생물역학측시（술후4、6주）관찰2조골절유합정황。결과재불동시간점，실험조여대조조상비，ER-β조단조적혈관생성，성골화궤계성능방면도명현점우세，2조비교차이구유통계학의의（P＜0．05）。결론조단 ER-β수체능명현제고조기혈관형성、중기적연골내골화화만기적궤계역학성능등골절수복능력。
Objective To discuss the effect of estrogen receptor ER-βon the repair of femoral fracture in elderly mice with osteoporosis.Methods Elderly mice with osteoporotic femoral frac-ture were given highly selective ER-βinhibitor (experimental group)or not (control group). Fracture healing was determined by radiological analysis (0,1,2,3,4,5 and 6 weeks after opera-tion),micro-CT analysis (1 and 2 weeks after operation)and biomechanical testing (4 and 6 weeks after operation).The results were compared between the two groups.Results Compared with control group,the angiogenesis,osteogenesis and mechanical capacity were obviously im-proved in experimental group at all time points (P<0.05).Conclusion The blockage of ER-βcan improve angiogenesis at early stage,endochondral ossification at middle stage and mechanical per-formance at late stage in elderly mice with osteoporotic fracture.