CAJ | 학술논문

【目的】观察炎琥宁分别联合西咪替丁与利巴韦林治疗流行性腮腺炎的有效性及安全性，为临床优化用药提供依据。【方法】将65例流行性腮腺炎患儿随机分为观察组33例和对照组32例，均静脉滴注炎琥宁10 mg/（kg·d）治疗，观察组合用西咪替丁15～20 mg/（kg·d）治疗，对照组合用利巴韦林10～15 mg/（kg· d）治疗，用药5 d后观察两组患者的临床疗效及安全性。【结果】观察组在退热时间、腮肿消退时间上均短于对照组，差异有统计学意义（P＜0．05）；观察组临床总有效率为93．94％，高于对照组的75．00％（P ＜0．05）；两组并发症发生率比较差异不显著（P＞0．05），均未出现严重不良反应。【结论】炎琥宁联合西咪替丁治疗流行性腮腺炎较联合利巴韦林安全有效，值得临床应用。
【목적】관찰염호저분별연합서미체정여리파위림치료류행성시선염적유효성급안전성，위림상우화용약제공의거。【방법】장65례류행성시선염환인수궤분위관찰조33례화대조조32례，균정맥적주염호저10 mg/（kg·d）치료，관찰조합용서미체정15～20 mg/（kg·d）치료，대조조합용리파위림10～15 mg/（kg· d）치료，용약5 d후관찰량조환자적림상료효급안전성。【결과】관찰조재퇴열시간、시종소퇴시간상균단우대조조，차이유통계학의의（P＜0．05）；관찰조림상총유효솔위93．94％，고우대조조적75．00％（P ＜0．05）；량조병발증발생솔비교차이불현저（P＞0．05），균미출현엄중불량반응。【결론】염호저연합서미체정치료류행성시선염교연합리파위림안전유효，치득림상응용。
[Objective]To observe the efficacy and safety of yanhuning combined with cimetidine or ribavi-rin for the treatment of mumps in order to provide the basis for clinical optimal medication.[Methods]A total of pediatric patients with mumps were randomly divided into observation group(n=33)and control group(n=32).All patients in two groups were treated with yanhuning 10mg/(kg·d)by intravenous drip.The ob-servation group was additionally treated with cimetidine 15~20mg/(kg·d),while the control group was addi-tionally treated with ribavirin 10~15mg/(kg·d).Clinical efficacy and safety of two groups 5d after treatment were observed.[Results]The fever clearance time and swollen extinction time in observation group were shor-ter than those in control group,and there was significant difference(P<0.05).Clinical total effective rate of observation group was 93.94%,which was higher than that of control group(75.00%)(P <0.05).There was no significant difference in the complication rate between two groups(P>0.05).No obvious adverse re-action occurred.[Conclusion]Yanhuning combined cimetidine for the treatment of mumps is more safe and ef-fective than yanhuning combined with ribavirin,so it is worthy of clinical application.