CAJ | 학술논문

【目的】观察冠心病及其不同分型患者血清中半乳糖凝集素-3（Gal-3）的水平，分析其与高敏 C反应蛋白（hs-CRP）、单核细胞趋化因子-1（MCP-1）的相关性，探讨 Gal-3在冠心病患者中的临床价值。【方法】收集经冠状动脉造影确诊的冠心病患者97例作为冠心病组，其中稳定性心绞痛组31例，不稳定心绞痛组35例，急性心肌梗死组31例，并收集冠脉造影正常的非冠心病患者30例作为对照组。采集入选病例一般临床资料，检测其血清 Gal-3、MCP-1及血浆 hs-CRP浓度。【结果】冠心病组血清 Gal-3水平明显高于对照组（P＜0．05），不稳定心绞痛组和急性心肌梗死组血清 Gal-3水平显著高于稳定性心绞痛组（P＜0．05），而急性心肌梗死组血清 Gal-3水平高于不稳定心绞痛组，但差异不具统计学意义（P ＞0．05）；冠心病患者血清 Gal-3水平与 hs-CRP、MCP-1水平显著正相关（P ＜0．05）。【结论】冠心病患者血清 Gal-3水平明显增高，血清Gal-3有望成为急性冠脉综合征新的生化标志物，具有重要的临床意义。联合检测 Gal-3、hs-CRP及 MCP-1对冠心病的早期诊断、危险分层及预后具有重要临床意义。
【목적】관찰관심병급기불동분형환자혈청중반유당응집소-3（Gal-3）적수평，분석기여고민 C반응단백（hs-CRP）、단핵세포추화인자-1（MCP-1）적상관성，탐토 Gal-3재관심병환자중적림상개치。【방법】수집경관상동맥조영학진적관심병환자97례작위관심병조，기중은정성심교통조31례，불은정심교통조35례，급성심기경사조31례，병수집관맥조영정상적비관심병환자30례작위대조조。채집입선병례일반림상자료，검측기혈청 Gal-3、MCP-1급혈장 hs-CRP농도。【결과】관심병조혈청 Gal-3수평명현고우대조조（P＜0．05），불은정심교통조화급성심기경사조혈청 Gal-3수평현저고우은정성심교통조（P＜0．05），이급성심기경사조혈청 Gal-3수평고우불은정심교통조，단차이불구통계학의의（P ＞0．05）；관심병환자혈청 Gal-3수평여 hs-CRP、MCP-1수평현저정상관（P ＜0．05）。【결론】관심병환자혈청 Gal-3수평명현증고，혈청Gal-3유망성위급성관맥종합정신적생화표지물，구유중요적림상의의。연합검측 Gal-3、hs-CRP급 MCP-1대관심병적조기진단、위험분층급예후구유중요림상의의。
[Objective]To observe serum level of galectin-3(Gal-3)in patients with different types of coro-nary heart disease and analyze its correlation with high-sensitivity C-reactive protein(hs-CRP)and monocyte chemokine protein-1(MCP-1),and to explore clinical value of Gal-3 in patients with coronary heart disease.[Methods]Totally 97 patients with coronary heart disease confirmed by coronary angiography were collected as coronary heart disease groups including stable angina pectoris group(group SA,n=31),unstable angina pec-toris group(group UA,n=35)and acute myocardial infarction(group AMI,n=31).Other 30 non-coronary heart disease patients with normal coronary angiography were collected as control group.General clinical data of all subjects were collected.Serum levels of Gal-3,MCP-1 and plasma hs-CRP were assayed.[Results]Ser-um Gal-3 level in coronary heart disease group was obviously higher that in control group(P<0.05).Serum Gal-3 levels in UA group and AMI group were markedly higher than those in SA group(P <0.05).Serum Gal-3 level in AMI group was higher than that in UA group,but there was significant difference(P>0.05). Serum Gal-3 level in patients with coronary heart disease was positively correlated with hs-CRP and MCP-1 significantly(P<0.05).[Conclusion]Serum Gal-3 level in patients with coronary heart disease is increased obviously,and may be a new biomarker for acute coronary syndrome,and has important clinical significance. Combined detection of Gal-3,hs-CRP and MCP-1 has important clinical significance in the early diagnosis,risk stratification and prognosis of coronary heart disease.