CAJ | 학술논문

【目的】探讨mTOR/p70S6K信号通路蛋白在Ⅱ级和Ⅲ级人脑胶质瘤组织中的表达及其与脑胶质瘤患者预后的关系。【方法】采用免疫组化方法，检测148例脑胶质瘤组织中 mTOR和 p70S6K的表达，并分析二者的相关性。通过Kaplan-Meier法分析mTOR和 p70S6K表达水平与无进展生存期（PFS）和总生存时间（OS）的关系。COX 回归模型分析各临床因素与预后的关系。【结果】Ⅱ级和Ⅲ级胶质瘤间 mTOR 和p70S6K表达水平相比较差异均有显著性（P ＜0．05），且 mTOR 和 p70S6K 的表达呈正相关关系（r ＝0．596，P＜0．01）。COX回归分析表明 p70S6K是影响胶质瘤患者预后的独立因素，p70S6K高表达患者较p70S6K低表达患者生存时间短（风险率：3．606；95％置信区间：1．066～12．201；P＝0．039）。mTOR的表达情况与预后不相关。【结论】p70S6K的表达水平对预测脑胶质瘤患者的预后有临床意义，可能成为脑胶质瘤基因治疗的潜在靶点。
【목적】탐토mTOR/p70S6K신호통로단백재Ⅱ급화Ⅲ급인뇌효질류조직중적표체급기여뇌효질류환자예후적관계。【방법】채용면역조화방법，검측148례뇌효질류조직중 mTOR화 p70S6K적표체，병분석이자적상관성。통과Kaplan-Meier법분석mTOR화 p70S6K표체수평여무진전생존기（PFS）화총생존시간（OS）적관계。COX 회귀모형분석각림상인소여예후적관계。【결과】Ⅱ급화Ⅲ급효질류간 mTOR 화p70S6K표체수평상비교차이균유현저성（P ＜0．05），차 mTOR 화 p70S6K 적표체정정상관관계（r ＝0．596，P＜0．01）。COX회귀분석표명 p70S6K시영향효질류환자예후적독립인소，p70S6K고표체환자교p70S6K저표체환자생존시간단（풍험솔：3．606；95％치신구간：1．066～12．201；P＝0．039）。mTOR적표체정황여예후불상관。【결론】p70S6K적표체수평대예측뇌효질류환자적예후유림상의의，가능성위뇌효질류기인치료적잠재파점。
[Objective]To explore the expression of mTOR/p70S6K signaling pathway in gradeⅡ-Ⅲ glio-mas and its correlation with the prognosis of patients with gliomas.[Methods]Immunohistochemical method was used to detect the expression of mTOR and p70S6K in 148 patients with gliomas.The correlation between them was analyzed.The relationship of the expression of mTOR and p70S6K with progression-free survival (PFS)and overall survival(OS)was analyzed by using Kaplan-Meier method.Cox regression model was used to analyze the correlation between all clinical factors and prognosis.[Results]There was significant difference between the expression of mTOR and p70S6K between grade Ⅱ and Ⅲ gliomas(P<0.05).There was posi-tive correlation between mTOR and p70S6K expression(r=0.596,P <0.01).Cox regression analysis re-vealed that p70S6K was an independent prognostic factor of gliomas patients.The survival time of patients with high expression of p70S6K was shorter than that of patients with low expression of p70S6K(hazard ratio=3.606;95% confidence interval=1.066~12.201;P=0.039).The expression of mTOR was not associat-ed with the prognosis.[Conclusion]The expression of p70S6K is of clinical significance in predicting the prog-nosis of patients with gliomas and may be the potential target for gene therapy of glioma.