中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY
2014年
6期
550-552
,共3页
黄芩提取物%抗炎作用%角叉菜胶%炎症介质%前列腺素E2
黃芩提取物%抗炎作用%角扠菜膠%炎癥介質%前列腺素E2
황금제취물%항염작용%각차채효%염증개질%전렬선소E2
scutellaria baicalensis Georgi%anti -inflammatory%carrag-eenan%inflammatory mediators%prostaglandin E 2
目的：研究黄芩提取物（ TESB ）抗炎作用及其机制。方法取角叉菜胶致大鼠足肿胀模型，将SD大鼠随机分为空白组（0.9％NaCl ）、模型组、阳性对照组，黄芩提取物低、中和高剂量组，灌胃给药5 d，观察黄芩提取物对角叉菜胶所致大鼠足肿胀炎症组织中前列腺素E2（PGE2）、丙二醛（MDA）及一氧化氮（NO）含量的影响。结果黄芩提取物对角叉菜胶所致大鼠足肿胀有显著的抑制作用，并呈剂量依赖关系。与模型组比较，黄芩提取物低、中、高剂量组均能抑制大鼠足肿胀组织中PGE2的含量，抑制率分别为19.6％，42.9％，66.1％；减少大鼠足肿胀组织中MDA的含量，抑制率分别为16.8％，39.9％，68.8％；减少大鼠足肿胀组织中NO的含量，抑制率分别为16.4％，48.4％，73.8％。结论黄芩提取物具有较好的抗炎活性，其作用可能是抑制脂质过氧化物的形成和影响炎症介质的释放。
目的：研究黃芩提取物（ TESB ）抗炎作用及其機製。方法取角扠菜膠緻大鼠足腫脹模型，將SD大鼠隨機分為空白組（0.9％NaCl ）、模型組、暘性對照組，黃芩提取物低、中和高劑量組，灌胃給藥5 d，觀察黃芩提取物對角扠菜膠所緻大鼠足腫脹炎癥組織中前列腺素E2（PGE2）、丙二醛（MDA）及一氧化氮（NO）含量的影響。結果黃芩提取物對角扠菜膠所緻大鼠足腫脹有顯著的抑製作用，併呈劑量依賴關繫。與模型組比較，黃芩提取物低、中、高劑量組均能抑製大鼠足腫脹組織中PGE2的含量，抑製率分彆為19.6％，42.9％，66.1％；減少大鼠足腫脹組織中MDA的含量，抑製率分彆為16.8％，39.9％，68.8％；減少大鼠足腫脹組織中NO的含量，抑製率分彆為16.4％，48.4％，73.8％。結論黃芩提取物具有較好的抗炎活性，其作用可能是抑製脂質過氧化物的形成和影響炎癥介質的釋放。
목적：연구황금제취물（ TESB ）항염작용급기궤제。방법취각차채효치대서족종창모형，장SD대서수궤분위공백조（0.9％NaCl ）、모형조、양성대조조，황금제취물저、중화고제량조，관위급약5 d，관찰황금제취물대각차채효소치대서족종창염증조직중전렬선소E2（PGE2）、병이철（MDA）급일양화담（NO）함량적영향。결과황금제취물대각차채효소치대서족종창유현저적억제작용，병정제량의뢰관계。여모형조비교，황금제취물저、중、고제량조균능억제대서족종창조직중PGE2적함량，억제솔분별위19.6％，42.9％，66.1％；감소대서족종창조직중MDA적함량，억제솔분별위16.8％，39.9％，68.8％；감소대서족종창조직중NO적함량，억제솔분별위16.4％，48.4％，73.8％。결론황금제취물구유교호적항염활성，기작용가능시억제지질과양화물적형성화영향염증개질적석방。
Objective To study the anti -inflammatory effect of the eth-anolic extract of Scutellaria baicalensis Georgi ( TESB ) and its mecha-nisms.Methods The rat paw edema model was taken by carrageenan -induced.The SD rats were randomly divided into blank group ( 0.9%NaCl ) , model group , positive control group , TESB of the low -dose group, middle dose group and high dose group .The duratoin was 5 days.The effects of TESB on carrageenan -induced production of prosta-glandin E2(PGE2), generation of malondialdehyde(MDA), nitric oxide ( NO) in the inflammatory tissue of rats were observed.Results TESB reduced carrageenan -induced rat paw oedema in dose -dependent man-ner, achieving high degree of anti -inflammatory activity.As compared with model group , TESB significantly inhibited the generation of PGE 2 by 19.6%, 42.9%, 66.1%, respectively; inhibited the generation of MDA by 16.8%, 39.9%, 68.8%, respectively;reduced the increased level of NO by 16.4%, 48.4%, 73.8%, respectively.Conclusion The scutellaria baicalensis Georgi is effective against inflammation , and this effect may be related to the inhibition on lipid peroxidation and in-flammatory mediators.
