中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY
2014年
6期
481-483
,共3页
非ST段抬高冠脉综合征%氯吡格雷%炎症因子%心功能
非ST段抬高冠脈綜閤徵%氯吡格雷%炎癥因子%心功能
비ST단태고관맥종합정%록필격뢰%염증인자%심공능
non ST segment elevation acute coronary syndrome%clopidogrel%inflammatory factor%cardiac function
目的:评价氯吡格雷对非ST段抬高冠脉综合征( NSTEACS )患者炎症因子及预后的影响。方法将我院收治的120例NSTEACS患者随机分为氯吡格雷联合阿司匹林组(观察组)和阿司匹林组(对照组),每组60例,分别于治疗前和治疗4周后检测炎症因子水平、心功能指标。结果治疗前,2组炎症因子水平、心功能指标的差异无统计学意义;治疗4周后,观察组和对照组的C-反应蛋白(CRP)(4.2±0.8) vs (7.1±1.3)mg· L-1,肿瘤坏死因子(TNF -α)(39.6±9.4) vs (66.9±11.4) pg· L-1,观察组均低于对照组;舒张早期充盈峰速度(E 峰)(76.4±14.9) vs (72.1±13.6)cm· s-1,E/A值(1.4±0.2) vs (1.3±0.2),左心室射血分数(LVEF)(69.3±11.3)% vs (64.1±7.5%),左心室舒张末期直径(LVEDD)(58.3±7.8) vs (54.1±8.7),观察组均高于对照组。E峰、E/A值、LVEF、LVEDD均与CRP、TNF-α含量呈负相关。结论氯吡格雷能够有效的降低炎症因子水平、改善远期心功能。
目的:評價氯吡格雷對非ST段抬高冠脈綜閤徵( NSTEACS )患者炎癥因子及預後的影響。方法將我院收治的120例NSTEACS患者隨機分為氯吡格雷聯閤阿司匹林組(觀察組)和阿司匹林組(對照組),每組60例,分彆于治療前和治療4週後檢測炎癥因子水平、心功能指標。結果治療前,2組炎癥因子水平、心功能指標的差異無統計學意義;治療4週後,觀察組和對照組的C-反應蛋白(CRP)(4.2±0.8) vs (7.1±1.3)mg· L-1,腫瘤壞死因子(TNF -α)(39.6±9.4) vs (66.9±11.4) pg· L-1,觀察組均低于對照組;舒張早期充盈峰速度(E 峰)(76.4±14.9) vs (72.1±13.6)cm· s-1,E/A值(1.4±0.2) vs (1.3±0.2),左心室射血分數(LVEF)(69.3±11.3)% vs (64.1±7.5%),左心室舒張末期直徑(LVEDD)(58.3±7.8) vs (54.1±8.7),觀察組均高于對照組。E峰、E/A值、LVEF、LVEDD均與CRP、TNF-α含量呈負相關。結論氯吡格雷能夠有效的降低炎癥因子水平、改善遠期心功能。
목적:평개록필격뢰대비ST단태고관맥종합정( NSTEACS )환자염증인자급예후적영향。방법장아원수치적120례NSTEACS환자수궤분위록필격뢰연합아사필림조(관찰조)화아사필림조(대조조),매조60례,분별우치료전화치료4주후검측염증인자수평、심공능지표。결과치료전,2조염증인자수평、심공능지표적차이무통계학의의;치료4주후,관찰조화대조조적C-반응단백(CRP)(4.2±0.8) vs (7.1±1.3)mg· L-1,종류배사인자(TNF -α)(39.6±9.4) vs (66.9±11.4) pg· L-1,관찰조균저우대조조;서장조기충영봉속도(E 봉)(76.4±14.9) vs (72.1±13.6)cm· s-1,E/A치(1.4±0.2) vs (1.3±0.2),좌심실사혈분수(LVEF)(69.3±11.3)% vs (64.1±7.5%),좌심실서장말기직경(LVEDD)(58.3±7.8) vs (54.1±8.7),관찰조균고우대조조。E봉、E/A치、LVEF、LVEDD균여CRP、TNF-α함량정부상관。결론록필격뢰능구유효적강저염증인자수평、개선원기심공능。
Objective To study the effect of clopidogrel on inflammatory factors and prognosis of patients with non ST segment elevationacute coro-nary syndrome ( NSTEACS ).Methods One hundred and twenty pa-tients with NSTEACS in our hospital were enrolled and randomly divided into observation group ( given aspirin combined with clopidogrel ) and control group ( only given aspirin ).Inflammatory factor level and heart function index were detected at pretreatment and 4-week treatment , re-spectively.Results Before treatment , the differences of inflammatory factor level and heart function indexe of two groups had no statistical sig-nificance;after 4 -week treatment , the levels of C -reactive protein ( CRP) ( 4.2 ±0.8 ) vs ( 7.1 ±1.3 ) mg · L-1 and tumor necrosis factor-α(TNF-α) (39.6 ±9.4) vs (66.9 ±11.4) pg· L-1 in ob-servation group were lower than those in control group.The values of E peak (76.4 ±14.9 ) vs (72.1 ±13.6 ) cm· s-1 , E/A (1.4 ±0.2 ) vs ( 1.3 ±0.2 ) , LVEF ( 69.3 ±11.3 )% vs ( 64.1 ±7.5 )%, and LVEDD (58.3 ±7.8 ) vs (54.1 ±8.7 ) in observation group were higher than those in control group.The values of E peak , E/A value, LVEF, LVEDD had negative correlation with the levels of CRP and TNF -α.Conclusion Clopidogrel can effectively decrease the levels of inflammatory factors and improve long -term heart function of patients with NSTEACS.