CAJ | 학술논문

目的：分析我院药品不良反应（ADR）的发生特点，为临床合理用药提供参考。方法：对我院2012年9月至2013年9月上报的225例ADR报告，从患者的性别、年龄、引发ADR的给药途径、药品种类、ADR累及器官或系统及临床表现、ADR严重程度及转归等方面进行回顾性分析。结果：女性ADR发生率高于男性，年龄在60岁以上的患者ADR发生率较其他年龄段高；静脉给药是引发ADR的主要给药途径；ADR涉及的药品种类以抗菌药物、中药制剂较多；ADR临床表现主要是消化系统损害，其次是皮肤及其附件损害。大部分ADR患者经停药或对症治疗后均痊愈或好转。结论：应加强ADR监测力度，加强对特殊人群、静脉给药方式、抗菌药物和中药注射剂等重点药物的ADR监测，提高合理用药水平，减少药源性疾病的发生。
목적：분석아원약품불량반응（ADR）적발생특점，위림상합리용약제공삼고。방법：대아원2012년9월지2013년9월상보적225례ADR보고，종환자적성별、년령、인발ADR적급약도경、약품충류、ADR루급기관혹계통급림상표현、ADR엄중정도급전귀등방면진행회고성분석。결과：녀성ADR발생솔고우남성，년령재60세이상적환자ADR발생솔교기타년령단고；정맥급약시인발ADR적주요급약도경；ADR섭급적약품충류이항균약물、중약제제교다；ADR림상표현주요시소화계통손해，기차시피부급기부건손해。대부분ADR환자경정약혹대증치료후균전유혹호전。결론：응가강ADR감측력도，가강대특수인군、정맥급약방식、항균약물화중약주사제등중점약물적ADR감측，제고합리용약수평，감소약원성질병적발생。
OBJECTIVE:To investigate the characteristics of the adverse drugs reactions(ADRs)in our hospital so as to pro-vide reference for clinical rational use of drugs. METHODS:225 ADR cases reported in our hospital during Sep. 2012-Sept. 2013 period,were analyzed retrospectively with regard to patients’age and gender,route of administration,drug types,ADR-involved organs or systems,clinical manifestation,severity and outcome of ADRs. RESULTS:The ADRs occurred mostly in females and in elderly patients over 60 years old and mostly via intravenous administration. The ADR-involved drugs were mainly antimicrobial drugs and traditional Chinese medicine preparations. The ADRs manifested mainly as gastrointestinal damage,followed by lesions of skin and its appendants,yet which were cured or recovered after drug discontinuation or symptomatic treatment. CONCLU-SIONS:We should strengthen the ADR monitoring in special group,during intravenous administration or when using such medi-cines as antimicrobial drugs and traditional Chinese medicine for injection in an effort to promote clinical rational use of drugs and reduce the incidences of drug-induced diseases.