CAJ | 학술논문

目的：建立湿法消解-电感耦合等离子体质谱法（ICP-MS）测定人血浆中乙烷硒啉的浓度，并将其用于乙烷硒啉分散片的人体药代动力学研究。方法血浆样品经硝酸消解后，用ICP-MS法测定给药后血浆中不同时间含硒药物总量，并用WinNonlin 5.2软件计算主要药代动力学参数。结果乙烷硒啉主要药代动力学参数如下：tmax为（9.20±0.98）h，Cmax为（597.58±221.73）ng· mL-1，AUC0-t为（2.57±0.92）μg· mL-1· h，平均滞留时间（ MRT）为（24.60±0.63） h。结论建立的ICP-MS法简便、快速、灵敏，适用乙烷硒啉分散片临床监测。
목적：건립습법소해-전감우합등리자체질보법（ICP-MS）측정인혈장중을완서람적농도，병장기용우을완서람분산편적인체약대동역학연구。방법혈장양품경초산소해후，용ICP-MS법측정급약후혈장중불동시간함서약물총량，병용WinNonlin 5.2연건계산주요약대동역학삼수。결과을완서람주요약대동역학삼수여하：tmax위（9.20±0.98）h，Cmax위（597.58±221.73）ng· mL-1，AUC0-t위（2.57±0.92）μg· mL-1· h，평균체류시간（ MRT）위（24.60±0.63） h。결론건립적ICP-MS법간편、쾌속、령민，괄용을완서람분산편림상감측。
Objective To establish inductively coupled plasma mass spectrometry ( ICP -MS ) method for determining the concentration of ethaselen in human plasma , and to apply it to the pharmacokinetic study of ethaselen dispersible tablets.Methods Plasma samples were digested with nitric acid , then detected by ICP -MS method.The main pharmaco-kinetic parameters were calculated with non -compartmental analysis by Wi-nNonlin 5.2 software.Results The parameters pharmacokinetic results of ethaselen were as follows: tmax was ( 9.20 ± 0.98 ) h, Cmax was (597.58 ±221.73) ng· mL-1, AUC0-t was (2.57 ±0.92) ng· h· mL-1, the mean residence time (MRT) was (24.60 ±0.63)h.Conclusion The ICP-MS method is simple, rapid and sensitive, which is suitable for clini-cal determination of the concentration of ethaselen dispersible tablets in hu-man plasma.