CAJ | 학술논문

目的：评价五水头孢唑林钠和头孢唑林钠在中国健康男性受试者体内的药代动力学。方法6名受试者单次静脉滴注五水头孢唑林钠2 g，2名受试者单次静脉滴注头孢唑林钠2 g，用HPLC法测定人血清和尿液中头孢唑林钠浓度。结果受试者单次静脉滴注五水头孢唑林钠和头孢唑林钠后主要药代动力学参数如下：tmax分别为（0.75±0），0.75 h，Cmax分别为（256.26±48.68），235.06μg· mL-1，t1/2分别为（2.44±0.46），2.20 h，AUC0-t分别为（635.19±87.98），500.86μg· h· mL-1。五水头孢唑林钠和头孢唑林钠24 h内原型药物尿中累积排泄百分率分别为（86.21±10.25）％，82.68％。结论受试药物与参比药物单次静脉滴注给药后在人体内主要药代动力学参数Cmax、t1/2、AUC0-t和AUC0-∞存在一定的差异。
목적：평개오수두포서림납화두포서림납재중국건강남성수시자체내적약대동역학。방법6명수시자단차정맥적주오수두포서림납2 g，2명수시자단차정맥적주두포서림납2 g，용HPLC법측정인혈청화뇨액중두포서림납농도。결과수시자단차정맥적주오수두포서림납화두포서림납후주요약대동역학삼수여하：tmax분별위（0.75±0），0.75 h，Cmax분별위（256.26±48.68），235.06μg· mL-1，t1/2분별위（2.44±0.46），2.20 h，AUC0-t분별위（635.19±87.98），500.86μg· h· mL-1。오수두포서림납화두포서림납24 h내원형약물뇨중루적배설백분솔분별위（86.21±10.25）％，82.68％。결론수시약물여삼비약물단차정맥적주급약후재인체내주요약대동역학삼수Cmax、t1/2、AUC0-t화AUC0-∞존재일정적차이。
Objective To evaluate the pharmacokinetics of cefazolin so-dium and cefazolin sodium pentahydrate in Chinese healthy volunteers af-ter intravenous injection.Methods Six healthy volunteers were admin-istrated of cefazolin sodium pentahydrate and the other two healthy volun-teers were administrated of cefazolin sodium whit a single dose of 2 g.Concentrations of cefazolin sodium in serum and urine were determined by HPLC method.Results The main pharmacokinetic parameters of ce-fazolin sodium pentahydrate and cefazolin sodium were as follows: tmax were(0.75 ±0),0.75 h,Cmax were(256.26 ±48.68), 235.06 μg· mL -1 , t1/2 were ( 2.44 ±0.46 ) , 2.20 h, AUC0-t were ( 635.19 ± 87.98 ) , 500.86 μg · h · mL-1 , respectively.Urinary recovery rate of cefazolin sodium pentahydrate and cefazolin sodium was ( 86.21 ± 10.25 )%, 82.68%, respectively.Conclusion The main pharmacoki-netics parameters such as Cmax , t1/2 , AUC0-t and AUC0-∞of test and ref-erence preparations had some differences.