CAJ | 학술논문

目的：评价五水头孢唑林钠与头孢唑林钠在比格犬体内的药代动力学特征。方法用单剂量、双周期、交叉实验设计。6只比格犬随机分为2组，单次静脉滴注五水头孢唑林钠或头孢唑林钠55 mg· kg-1，洗脱期7 d，用HPLC法测定比格犬血浆中头孢唑林钠浓度，用DAS 2.0软件计算药代动力学参数。结果受试药物与参比药物的主要药代动力学参数：t1/2分别为（1.34±0.15），（1.31±0.17） h；Cmax分别为（181.14±28.13），（171.18±24.70）μg· mL-1；tmax分别为（0.75±0.10），（0.71±0.10） h；AUC0-t分别为（342.57±76.02），（323.33±40.59）μg· h· mL-1。结论单次静脉滴注受试药物与参比药物在比格犬体内AUC0-t、AUC0-∞和Cmax药代动力学参数存在一定的差异。
목적：평개오수두포서림납여두포서림납재비격견체내적약대동역학특정。방법용단제량、쌍주기、교차실험설계。6지비격견수궤분위2조，단차정맥적주오수두포서림납혹두포서림납55 mg· kg-1，세탈기7 d，용HPLC법측정비격견혈장중두포서림납농도，용DAS 2.0연건계산약대동역학삼수。결과수시약물여삼비약물적주요약대동역학삼수：t1/2분별위（1.34±0.15），（1.31±0.17） h；Cmax분별위（181.14±28.13），（171.18±24.70）μg· mL-1；tmax분별위（0.75±0.10），（0.71±0.10） h；AUC0-t분별위（342.57±76.02），（323.33±40.59）μg· h· mL-1。결론단차정맥적주수시약물여삼비약물재비격견체내AUC0-t、AUC0-∞화Cmax약대동역학삼수존재일정적차이。
Objective To evaluate the pharmacokinetics parameters of cefazolin sodium pentahydrate and cefazolin sodium in beagle dogs after intravenous injection.Methods Six healthy beagle dogs were involved in the single -dose, double -cycle, randomized, and cross -over study.Six dogs were randomly divided into two groups , and each was given a single dose of 55 mg · kg -1 cefazolin sodium pentahydrate or ce-fazolin sodium in order to study pharmacokinetics of cefazolin sodium in plasma.The washout period lasted for 7 days.Concentrations were deter-mined by HPLC method.The pharmacokinetics parameters were evalua-ted by DAS 2.0 software.Results The main pharmacokinetic parameters of cefazolin sodium test and reference preparations were as follows:t1/2 were (1.34 ±0.15), (1.31 ±0.17 ) h; Cmax were(181.14 ±28.13 ), ( 171.18 ± 24.70 ) μg · mL-1; tmax were ( 0.75 ± 0.10 ) , (0.71 ±0.10) h;AUC0-t were(342.57 ±76.02), (323.33 ±40.59)μg · h · mL-1.Conclusion After single intravenous administration , there are differences between pharmacokinetic parameters of the test and the reference drugs in beagle dogs , such as AUC0-t, AUC0-∞ and Cmax.