CAJ | 학술논문

目的：评价帕罗西汀联合小剂量喹硫平治疗广泛性焦虑障碍的疗效及安全性。方法140例广泛性焦虑障碍患者随机分为治疗组（帕罗西汀联合小剂量喹硫平，71例）和对照组（帕罗西汀组，69例）。分别于治疗前及治疗后第1，2，4，6，8周末用汉密尔顿焦虑量表（ HAMA）评定疗效，治疗副反应量表（ TESS）评定药物不良反应，匹兹堡睡眠质量指数（ PSQI ）进行睡眠状况自评。结果观察8周，治疗组和对照组在治愈率（70.4％/68.1％）、显著改善率（15.5％/13.0％）、进步率（8.5％/10.1％）、无效率（5.6％/8.7％）方面差异无统计学意义（P＞0.05）。治疗组在治疗1周末HAMA总分即有明显下降（ P＜0.05）；对照组从2周末开始明显下降（P＜0.05）。治疗组1，2，4周末精神焦虑因子较对照组差异有统计学意义（P＜0.05或P＜0.01）；2，4周末躯体焦虑因子分较对照组差异有统计学意义（P＜0.05或P＜0.01）。治疗后，治疗组与对照组PSQI评分差异有统计学意义（ P＜0.05或P＜0.01）。2组均未发现明显药物不良反应。结论帕罗西汀联合小剂量喹硫平治疗广泛性焦虑症起效早、安全性好，患者依从性好。
목적：평개파라서정연합소제량규류평치료엄범성초필장애적료효급안전성。방법140례엄범성초필장애환자수궤분위치료조（파라서정연합소제량규류평，71례）화대조조（파라서정조，69례）。분별우치료전급치료후제1，2，4，6，8주말용한밀이돈초필량표（ HAMA）평정료효，치료부반응량표（ TESS）평정약물불량반응，필자보수면질량지수（ PSQI ）진행수면상황자평。결과관찰8주，치료조화대조조재치유솔（70.4％/68.1％）、현저개선솔（15.5％/13.0％）、진보솔（8.5％/10.1％）、무효솔（5.6％/8.7％）방면차이무통계학의의（P＞0.05）。치료조재치료1주말HAMA총분즉유명현하강（ P＜0.05）；대조조종2주말개시명현하강（P＜0.05）。치료조1，2，4주말정신초필인자교대조조차이유통계학의의（P＜0.05혹P＜0.01）；2，4주말구체초필인자분교대조조차이유통계학의의（P＜0.05혹P＜0.01）。치료후，치료조여대조조PSQI평분차이유통계학의의（ P＜0.05혹P＜0.01）。2조균미발현명현약물불량반응。결론파라서정연합소제량규류평치료엄범성초필증기효조、안전성호，환자의종성호。
Objective To investigate the efficacy and safety of paroxe-tine combined with low dose of quetiapine in the treatment of generalized anxiety disorder.Methods One hundred and forty patients with gener-alized anxiety disorder were randomly assigned to treatment group ( parox-etine combined with low dose of quetiapine group , n =71 ) and control group ( paroxetine group , n =69 ).The efficacy was assessed by the Hamilton rating scale for anxiety ( HAMA ) , the Treatment Emergent Symptom Scale ( TESS ) for side effects , and Pittsburgh sleep quality in-dex(PSQI)for sleep qualities of all participants at baseline and at the end of 1st, 2nd, 4th, 6th, 8thweek.Results There were no significant differ-ences between two groups at cure rate ( 70.4%/68.1%) , notable im-provement rate ( 15.5%/13.0%) , progress rate ( 8.5%/10.1%) , and ineffective rate ( 5.6%/8.7%) overall the treatment course.Compare with the baseline , the treatment group showed notable decrease of HAMA at the 1 st weekend ( P<0.05 ) , and the control group showed that at the 2nd weekend (P<0.05).The treatment group had a more significant de-crease than the control group at the 1st, 2nd, and 4th week end(P<0.05 or P<0.01 ).The psychic anxiety score of the treatment group at the 1st, 2nd, 4th weekend and the somatic anxiety score at the 2nd, 4th weekend showed significant decrease ,compared with the control group ( P<0.05 or P<0.01 ).Both of the two group had no serious adverse events.Conclusion Paroxe-tine combined with low dose of quetiapine is an effective and safe way to treat generalized anxiety disorder , and patients have good compliance under the treatment.