CAJ | 학술논문

目的：评价鸦胆子油乳对晚期结直肠癌疗效和生存质量的影响。方法晚期结直肠癌患者130例随机分为治疗组和对照组，各65例，治疗组用鸦胆子油乳联合奥沙利铂＋亚叶酸钙＋氟脲嘧啶（ mFOLFOX6）方案治疗，对照组仅用mFOLFOX6方案治疗，比较2组的客观缓解率（ ORR）、疾病控制率（ DCR）、肿瘤进展时间（ TTP）、毒副反应和 Karnofsky 功能状态评分（ KPS）、生活质量评分（ QOL）。结果可评价患者125例，其中治疗组63例，对照组62例。治疗组的 ORR、TTP高于对照组[65.08％ vs 41.94％， P＜0.05；（13.49±3.90）个月 vs （9.26±4.66）个月， P ＜0.01）]， KPS 评分、QOL改善均显著优于对照组（ P＜0.01）；骨髓抑制发生率低于对照组（42.86％ vs 69.35％，P＜0.01）；2组DCR及在胃肠道反应和神经不良反应差异无统计学意义（均 P＞0.05）。结论加用鸦胆子油乳治疗晚期结直肠癌可提高临床疗效，延长TTP，改善生存质量，减轻骨髓抑制。
목적：평개아담자유유대만기결직장암료효화생존질량적영향。방법만기결직장암환자130례수궤분위치료조화대조조，각65례，치료조용아담자유유연합오사리박＋아협산개＋불뇨밀정（ mFOLFOX6）방안치료，대조조부용mFOLFOX6방안치료，비교2조적객관완해솔（ ORR）、질병공제솔（ DCR）、종류진전시간（ TTP）、독부반응화 Karnofsky 공능상태평분（ KPS）、생활질량평분（ QOL）。결과가평개환자125례，기중치료조63례，대조조62례。치료조적 ORR、TTP고우대조조[65.08％ vs 41.94％， P＜0.05；（13.49±3.90）개월 vs （9.26±4.66）개월， P ＜0.01）]， KPS 평분、QOL개선균현저우우대조조（ P＜0.01）；골수억제발생솔저우대조조（42.86％ vs 69.35％，P＜0.01）；2조DCR급재위장도반응화신경불량반응차이무통계학의의（균 P＞0.05）。결론가용아담자유유치료만기결직장암가제고림상료효，연장TTP，개선생존질량，감경골수억제。
Objective To evaluate the effect of bruceolic oil emulsion on the advanced colorectal carcinoma and life quality of patients.Meth-ods One hundred and thirty patients with advanced colorectal cancer were randomly divided into treatment group ( n=65 ) and control group ( n=65 ).The patients in treatment group were treated with bruceolic oil emulsion combined with mFOLFOX6,and those in the control group only with mFOLFOX6.The objective response rate (ORR)、disease control rate ( DCR ) , time to tumor progression ( TTP ) , toxicities and Karnofsky scores ( KPS) , and quality of life scores ( QOL) in two groups were com-pared.Resultes The 125 evaluable patients were assigned into the treatment group ( 63 patients ) and the control group ( 62 patients ) .The ORR and TTP in the treatment group were higher than in the control group [ 65.08% vs 41.94%, P <0.05;( 13.49 ±3.90 ) months vs (9.26 ±4.66 ) months,P<0.01 )].The treatment group was signifi-cantly superior to the control group in KPS and QOL ( P<0.01 ).The occurrence of bone marrow suppression was significantly lower than that in the control group ( 42.86% vs 69.35%, P<0.01 ).There were no significant differences between the two groups in DCR ( 77.77% vs 72.59%, P >0.05 ) , gastrointestinal reactions and neurotoxicity ( P>0.05 ).Conclusion Bruceolic oil emulsion could improve the clinical curative effect , extend TTP, improve the life quality of patients and decrease marrow suppression in treating advanced colorectal carcinoma.