CAJ | 학술논문

目的：对培哚普利治疗高血压的疗效及安全性进行系统评价。方法：通过对Embase、Medline、Cochrane图书馆、PubMed及中国知网、万方、维普等中外数据库进行检索，筛选临床随机对照试验文献进行评价分析。按照文献质量评价标准严格评价文献，纳入高质量的研究文献。对培哚普利的疗效进行Meta分析，并对其安全性进行分析比较。结果：培哚普利具有良好的降压效果，与安慰剂、对照药物及常规降压药相比，其降压效果都有一定优势；且该药物的不良反应较少、症状较轻微。结论：培哚普利治疗高血压，临床疗效较好，安全性良好。
목적：대배타보리치료고혈압적료효급안전성진행계통평개。방법：통과대Embase、Medline、Cochrane도서관、PubMed급중국지망、만방、유보등중외수거고진행검색，사선림상수궤대조시험문헌진행평개분석。안조문헌질량평개표준엄격평개문헌，납입고질량적연구문헌。대배타보리적료효진행Meta분석，병대기안전성진행분석비교。결과：배타보리구유량호적강압효과，여안위제、대조약물급상규강압약상비，기강압효과도유일정우세；차해약물적불량반응교소、증상교경미。결론：배타보리치료고혈압，림상료효교호，안전성량호。
OBJECTIVE:To conduct a systemic evaluation on the efficacy and safety of perindopril for the treatment of hyper-tension. METHODS:The randomized clinical trials (RCTs) retrieved from the databases both at home and abroad including Em-base,Medline,Cochrane Library,PubMed,CNKI,Wanfang and VIP were analyzed and evaluated in accordance with the related criteria for literature evaluation,and the RCTs with high quality was included in our study. The efficacy of perindopril for hyperten-sion was given meta-analysis and its safety was analyzed comparatively. RESULTS:Perindopril showed better antihypertensive effi-cacy than placebo,control or other routine antihypertensive drugs yet with fewer adverse effects and milder symptoms. CONCLU-SIONS:Perindopril can be used for hypertension with good efficacy and safety.