CAJ | 학술논문

目的：探讨围孕期妇女补充叶酸预防神经管畸形的效果。方法：对2004年1月至2013年9月在我院建档、检查的围孕期妇女的资料进行回顾性分析和总结，分别将不同时间段分娩的围产儿及神经管畸形儿作为对照组（2004-2008年）和观察组（2009年至2013年9月），通过对两组资料进行分析比较，了解孕期妇女补充叶酸预防神经管畸形的效果。结果：对照组发生神经管畸形9例，观察组发生2例，两组比较差异具有统计学意义（P＜0.05）。结论：围孕期妇女补充小剂量叶酸是预防神经管畸形的重要手段，可有效降低胎儿神经管畸形的发生率；应对育龄妇女加强服用叶酸的宣教。
목적：탐토위잉기부녀보충협산예방신경관기형적효과。방법：대2004년1월지2013년9월재아원건당、검사적위잉기부녀적자료진행회고성분석화총결，분별장불동시간단분면적위산인급신경관기형인작위대조조（2004-2008년）화관찰조（2009년지2013년9월），통과대량조자료진행분석비교，료해잉기부녀보충협산예방신경관기형적효과。결과：대조조발생신경관기형9례，관찰조발생2례，량조비교차이구유통계학의의（P＜0.05）。결론：위잉기부녀보충소제량협산시예방신경관기형적중요수단，가유효강저태인신경관기형적발생솔；응대육령부녀가강복용협산적선교。
OBJECTIVE:To investigate the preventive efficacy of periconceptional folic acid supplementation against neural tube defects. METHODS:The data of the pregnant women receiving filed and examined in our hospital from 2004 to Sept. 2013 were retrospectively analyzed and summarized. The perinatal babies and those with neural tube defects delivered at different time pe-riod were assigned to either control group(2004-2008)or observation group(2009-Sept. 2013),with the preventive efficacy of folic acid supplementation against neural tube defects evaluated through contrast analysis of the related data in the two groups. RE-SULTS:9 cases in the control group versus 2 cases in the observation group presented with neural tube defects,and the differences between the two groups were statistically significant(P<0.05). CONCLUSIONS:Periconceptional folic acid supplementation is of great importance for prevention of neural tube defects. It is important to emphasize the propaganda of folic acid supplementation in women of reproductive age.