CAJ | 학술논문

目的：评价参附注射液对扩张型心肌病（ DCM ）伴心力衰竭患者心功能的临床改善及对血浆中脑钠肽（ BNP ）、血管紧张素Ⅱ（ Ang -Ⅱ）、内皮素（ ET-Ⅰ）的影响。方法将80例DCM伴心力衰竭患者随机分为对照组和治疗组，每组各40例，对照组给予常规西药治疗，治疗组在西药常规治疗基础上静脉滴注参附注射液50 mL，每日1次，疗程均为2周。观察患者治疗前后临床心功能改善、6分钟步行距离、及血浆中BNP、Ang-Ⅱ、ET-Ⅰ的变化。结果治疗后，治疗组心功能分级、6分钟步行距离改善明显优于对照组（ P＜0.05）。2组患者血浆中BNP、Ang-Ⅱ、ET-Ⅰ治疗后均较治疗前明显下降，治疗组较对照组下降更明显（ P＜0.05）。结论参附注射液能够改善DCM伴心力衰竭患者的心功能，且对神经内分泌的激活有干预作用。
목적：평개삼부주사액대확장형심기병（ DCM ）반심력쇠갈환자심공능적림상개선급대혈장중뇌납태（ BNP ）、혈관긴장소Ⅱ（ Ang -Ⅱ）、내피소（ ET-Ⅰ）적영향。방법장80례DCM반심력쇠갈환자수궤분위대조조화치료조，매조각40례，대조조급여상규서약치료，치료조재서약상규치료기출상정맥적주삼부주사액50 mL，매일1차，료정균위2주。관찰환자치료전후림상심공능개선、6분종보행거리、급혈장중BNP、Ang-Ⅱ、ET-Ⅰ적변화。결과치료후，치료조심공능분급、6분종보행거리개선명현우우대조조（ P＜0.05）。2조환자혈장중BNP、Ang-Ⅱ、ET-Ⅰ치료후균교치료전명현하강，치료조교대조조하강경명현（ P＜0.05）。결론삼부주사액능구개선DCM반심력쇠갈환자적심공능，차대신경내분비적격활유간예작용。
Objective To evaluate the clinical efficacy of Shenfu injec-tion on cardiac function of patients with dilated cardiomyopathy ( DCM ) associated with heart failure ( HF ) and its influence on brain natriuretic peptide ( BNP) , angiotensinⅡ( Ang-Ⅱ) , endothelin ( ET-Ⅰ) in plas-ma.Methods Eighty patients with DCM associated with HF were ran-domly divided into treatment group (n=40) and control group (n=40).Patients in the control group were only given conventional treatment of western medicine for two weeks , while patients in the treatment group were treated with Shenfu injection 50 mL on the basis of the conventional treat-ment for two weeks.The cardiac function,6 -minute walk test, and the change of BNP , Ang-Ⅱ, ET-Ⅰwere observed before and after treatment.Results The cardiac function and 6-minute walk test of the Shenfu treat-ment group improved remarkably compared with control group (P<0.05).The levels of BNP , Ang-Ⅱ, ET-Ⅰin both groups decreased significantly after treatment (P<0.05), and that in treatment group decreased more ob-viously compared with control group (P<0.05).Conclusion Shenfu in-jection can improve cardiac function of patients with DCM associated with HF, which also has therapeutic effects on the activation of neuroendocrine.