CAJ | 학술논문

循环游离核酸是指存在于人体血液循环中，游离于细胞外的微量内源性或外源性核酸片段。肿瘤患者的血液中游离核酸的含量明显高于健康人群，并具有与肿瘤的发生、发展相关的特征性改变，如基因突变、甲基化、杂合性丢失、片段完整性改变、microRNA的异常表达等。对血液中游离核酸的定性与定量检测，在肿瘤的筛查、诊断、个体化治疗方案的制定、病情的监测以及预后评价中均有潜在的价值。
순배유리핵산시지존재우인체혈액순배중，유리우세포외적미량내원성혹외원성핵산편단。종류환자적혈액중유리핵산적함량명현고우건강인군，병구유여종류적발생、발전상관적특정성개변，여기인돌변、갑기화、잡합성주실、편단완정성개변、microRNA적이상표체등。대혈액중유리핵산적정성여정량검측，재종류적사사、진단、개체화치료방안적제정、병정적감측이급예후평개중균유잠재적개치。
Circulating cell-free nucleic acids are defined as extracellular DNAs or RNAs in blood with physiological or pathological origins. Previous studies showed that the concentration of cell-free nucleic acids in the blood of cancer patients is significantly higher than in healthy people. Further studies showed that the genetic and epigenetic alterations of circulating cell-free nucleic acids are relevant to cancer development and progression, including mutation, hypermethylation, loss of heterozygosity, change of integrity, and abnormal expression of microRNAs. Detection of circulating cell-free nucleic acids shows promising potential in cancer screening, diagnosis, personalized treatment, and prognosis.