CAJ | 학술논문

目的：探讨自制二级镀铜铂金微弹簧圈对兔血管栓塞的效果。方法选取新西兰大耳兔17只,采用自制的二级镀铜铂金微弹簧圈(实验组)经3 F 微导管释放,栓塞一侧锁骨下动脉或颈总动脉,然后再采用相同规格的二级铂金微弹簧圈(对照组)栓塞对侧锁骨下动脉或颈总动脉作栓塞对照分析。分别于栓塞前后不同时间测肝、肾功能及血清铜离子浓度；于栓塞术后不同时间观察血管闭塞情况和病理学改变。结果17只兔中15只完成栓塞实验。栓塞术后,血清铜离子术后2周内较术前升高,差异有显著性意义(P <0.05),4周后与术前比较,差异无显著性意义(P >0.05)；肝、肾功能2周后恢复至术前水平。栓塞后10 min、30 min,血管造影显示,2组间血管栓塞效果差异无统计学意义,3 d、1周、2周、4周、6周、12周时,实验组血管栓塞的效果均优于对照组,差异有统计学意义(P 值均<0.01)。病理检查显示,实验组铜圈周围及其内部、血管远近端有大量的血栓。对照组弹簧圈周围仅见少量血栓,实验组各观察点的血栓形成情况均优于对照组(P 值均<0.01)。但2组间炎性细胞浸润情况差异无统计学意义。结论二级镀铜铂金微弹簧栓塞效果肯定,其记忆性、柔韧性、可控性、释放性及稳定性优于二级铂金微弹簧圈。
목적：탐토자제이급도동박금미탄황권대토혈관전새적효과。방법선취신서란대이토17지,채용자제적이급도동박금미탄황권(실험조)경3 F 미도관석방,전새일측쇄골하동맥혹경총동맥,연후재채용상동규격적이급박금미탄황권(대조조)전새대측쇄골하동맥혹경총동맥작전새대조분석。분별우전새전후불동시간측간、신공능급혈청동리자농도；우전새술후불동시간관찰혈관폐새정황화병이학개변。결과17지토중15지완성전새실험。전새술후,혈청동리자술후2주내교술전승고,차이유현저성의의(P <0.05),4주후여술전비교,차이무현저성의의(P >0.05)；간、신공능2주후회복지술전수평。전새후10 min、30 min,혈관조영현시,2조간혈관전새효과차이무통계학의의,3 d、1주、2주、4주、6주、12주시,실험조혈관전새적효과균우우대조조,차이유통계학의의(P 치균<0.01)。병리검사현시,실험조동권주위급기내부、혈관원근단유대량적혈전。대조조탄황권주위부견소량혈전,실험조각관찰점적혈전형성정황균우우대조조(P 치균<0.01)。단2조간염성세포침윤정황차이무통계학의의。결론이급도동박금미탄황전새효과긍정,기기억성、유인성、가공성、석방성급은정성우우이급박금미탄황권。
Objective To evaluate the embolic effect on rabbits arteries using self-made copper plated platinum coil.Methods 1 7 New Zealand Big Ear Rabbits were selected.Unilateral subclavian artery or carotid artery was embolized with self-made secondary level copper plated platinum micro-coils (experimental group)through 3F-catheter.Contralateral subclavian artery or carotid artery was also embolized using secondary level platinum micro-coils (control group)as a control.The level of serum copper ions and the liver and renal function were recorded during different intervals before and after embolization.The arteriography and the tissue his-tology were observed respectively during different intervals after the embolization.Results 1 5 of 1 7 rabbits were embolized success-fully.After embolization,the level of serum copper ions increased in 2 weeks(P <0.05).However,it returned to preoperative level after 4 weeks (P >0.05).The liver and renal function was similar to that of the preoperation after 2 weeks.After embolization,an-giography showed that vascular embolization effect between two groups was not significantly different at 10 min and 30 min;howev-er,the embolization effect of experimental group was superior to that of control one (P <0.01)at 3 days and 1 week,2 weeks,4 weeks,6 weeks and 12 weeks.Pathological results showed that there were a lot of thromboses inside,outside and around the copper coil.Few thromboses appeared around platinum coil in control group.The thrombosis situation in experiment group was better than that in control one (P <0.01).However,no significant difference in inflammatory cell infiltration between two groups was found. Conclusion Self-made secondary level copper plated platinum coil has good physical property,rememorability,flexibility and con-trollability.