CAJ | 학술논문

目的：探讨治糜康栓联合宫颈环形电切术（loop electrosurgical excision procedure ，LEEP）治疗宫颈上皮内瘤变（cervical intraepithelial neoplasia ，CIN）伴人乳头状瘤病毒（human papilloma virus，HPV）感染的临床疗效。方法按照随机数字表法将76例CIN伴HPV感染患者均分为试验组和对照组，均给予LEEP治疗，试验组加用治糜康栓治疗。比较2组患者阴道出血、排液、宫颈创面愈合情况、临床疗效以及HPV转阴率。结果试验组患者术后阴道排液量、排液时间、出血量、出血时间、盆腔疼痛发生率及宫颈创面愈合时间均明显低于对照组，差异具有统计学意义（ P＜0．05）；试验组患者显效率和HPV转阴率均明显高于对照组，差异具有统计学意义（ P＜0．05）。结论治糜康栓联合LEEP治疗CIN伴HPV感染临床疗效显著，能够有效改善患者临床症状，安全性高。
목적：탐토치미강전연합궁경배형전절술（loop electrosurgical excision procedure ，LEEP）치료궁경상피내류변（cervical intraepithelial neoplasia ，CIN）반인유두상류병독（human papilloma virus，HPV）감염적림상료효。방법안조수궤수자표법장76례CIN반HPV감염환자균분위시험조화대조조，균급여LEEP치료，시험조가용치미강전치료。비교2조환자음도출혈、배액、궁경창면유합정황、림상료효이급HPV전음솔。결과시험조환자술후음도배액량、배액시간、출혈량、출혈시간、분강동통발생솔급궁경창면유합시간균명현저우대조조，차이구유통계학의의（ P＜0．05）；시험조환자현효솔화HPV전음솔균명현고우대조조，차이구유통계학의의（ P＜0．05）。결론치미강전연합LEEP치료CIN반HPV감염림상료효현저，능구유효개선환자림상증상，안전성고。
Objective To explore the clinical effects of Zhimingkang Shuan combined with LEEP for CIN patients with HPV.Methods 76 cases of CIN patients with HPV were randomly divided into the experiment group and the control group .All of them were treated by LEEP ,and the experiment group were additionally treated by Zhimingkang Shuan .Vaginal bleeding ,un-load liquid,the cervical wound healing ,clinical effects and HPV negative conversion ratio of the 2 groups were compared .Results The vaginal drainage quantity ,cleanup time ,bleeding volume ,bleeding time ,the incidence of pelvic pain and the cervical wound healing time in the experiment group were lower than those of the control group ( P<0.05);The significant efficiency and negative conversion ratio of HPV in the experiment group were higher than those of the control group (P<0.05).Conclusion Zhiming-kang Shuan combined with LEEP for CIN patients with HPV has remarkable clinical effects ,and it can improve the clinical symp-toms with high safety .