CAJ | 학술논문

目的：探讨肝癌患者精确放疗后乙型肝炎病毒（hepatitis B virus，HBV）再激活的危险因素。方法对70例肝癌患者的临床诊断资料进行回顾性分析，采用Logistic回归分析法评估各临床指标对HBV病毒再激活的影响情况。结果随访20周后，HBV病毒再激活发生率为25．71％。经Logistic单因素筛选及多因素分析后，HBV DNA水平是HBV病毒再激活的独立危险因素（P＜0．05）。结论肝癌患者精确放疗后存在较高的HBV再激活风险，与基线血清HBV DNA水平有密切关系。
목적：탐토간암환자정학방료후을형간염병독（hepatitis B virus，HBV）재격활적위험인소。방법대70례간암환자적림상진단자료진행회고성분석，채용Logistic회귀분석법평고각림상지표대HBV병독재격활적영향정황。결과수방20주후，HBV병독재격활발생솔위25．71％。경Logistic단인소사선급다인소분석후，HBV DNA수평시HBV병독재격활적독립위험인소（P＜0．05）。결론간암환자정학방료후존재교고적HBV재격활풍험，여기선혈청HBV DNA수평유밀절관계。
Objective To investigate the risk factors of hepatitis B virus reactivation induced by precise radiotherapy in patients with hepatic carcinoma .Methods The clinical data of 70 patients with hepatic carcinoma were analyzed retrospectively . Logistic regression analysis was used to evaluate the association of clinical indictors with HBV reactivation .Results After 20 weeks of follow-up,the incidence rate of HBV reactivation was 25.71%.After Logistic single factor screening and multi-factor a-nalysis,baseline serum HBV DNA level was the risk factor for HBV reactivation after precise radiotherapy (P<0.05).Conclu-sion Patients with hepatocellular carcinoma have a higher risk of HBV reactivation after precise radiotherapy ,and it is related to the DNA level of baseline serum HBV closely .