CAJ | 학술논문

目的：探讨口服双环醇对奥沙利铂联合卡培他滨方案治疗胃癌患者引起的肝损伤的治疗作用和预防作用。方法选取58例应用奥沙利铂联合卡培他滨方案治疗胃癌后出现肝损伤的患者，采用口服双环醇150 mg/d治疗，待肝功能正常后再按原化疗方案治疗，同时服用双环醇片进行预防。比较2种化疗方式的ALT、AST、TBiL的差值。结果肝损害后口服双环醇片可以明显降低肝功能ALT、AST指标（t＝10．076、4．043，P＜0．001），患者在服用双环醇片后约9天（中位时间）后肝功能恢复正常。与单纯化疗相比，联合双环醇一起化疗可以使治疗前后ALT、AST的差值显著减小（t＝6．423、2．960，P＜0．05）。结论口服双环醇可以治疗和预防奥沙利铂联合卡培他滨治疗胃癌引起的肝损伤。
목적：탐토구복쌍배순대오사리박연합잡배타빈방안치료위암환자인기적간손상적치료작용화예방작용。방법선취58례응용오사리박연합잡배타빈방안치료위암후출현간손상적환자，채용구복쌍배순150 mg/d치료，대간공능정상후재안원화료방안치료，동시복용쌍배순편진행예방。비교2충화료방식적ALT、AST、TBiL적차치。결과간손해후구복쌍배순편가이명현강저간공능ALT、AST지표（t＝10．076、4．043，P＜0．001），환자재복용쌍배순편후약9천（중위시간）후간공능회복정상。여단순화료상비，연합쌍배순일기화료가이사치료전후ALT、AST적차치현저감소（t＝6．423、2．960，P＜0．05）。결론구복쌍배순가이치료화예방오사리박연합잡배타빈치료위암인기적간손상。
Objective To evaluate the efficacy of bicyclol in the prevention and treatment of hepatic damage caused by oxalipaltin plus capecitabine for gastric cancer .Methods 58 gastric cancer patients received bicyclol 150mg/d orally for hepatic damage caused by oxalipaltin and capecitabine .After the recovery of liver damage , they resumed the same chemotherapeutic scheme ,taking bicyclol to prevent the hepatic damage at the same time .Difference of ALT、AST、TBiL between the 2 chemothera-py were compared.Results Bicyclol could significantly decrease the ALT and AST level caused by chemotherapy (t=10.076、4.043,P<0.001).9 days (median time) after taking bicyclol,patients’ liver function recovered.Compared with chemotherapy without bicyclol ,the combination cure of bicyclol and chemotherapy could reduce the difference -value before and after the treat-ment(t=6.423、2.960,P<0.05).Conclusion Bicyclol can treat and protect liver damage caused by oxalipaltin plus capecit -abine for gastric cancer .