CAJ | 학술논문

目的：分析ERCC1和TS对预测采用奥沙利铂和5-Fu联合化疗胃癌患者化疗疗效的作用。方法检索纳入5篇（从2008年到2013年）国际和国内有关ERCC1和TS关于预测5-Fu和奥沙利铂对于胃癌化疗疗效的文献，应用随机效应模型和固定效应模型进行综合的定量分析，软件为RevMan5．0。结果 ERCC1对采用5-Fu和奥沙利铂联合化疗的胃癌患者化疗疗效的RR值为0．74，95％CI为0．58-0．95。 TS对采用5-Fu和奥沙利铂联合化疗的胃癌患者化疗疗效的RR值为7．55，95％CI为4．47-12．76。结论 ERCC1阴性的胃癌患者，采用5-Fu和奥沙利铂化疗的疗效更好。TS阳性的胃癌患者，采用5-Fu和奥沙利铂化疗的疗效更好。
목적：분석ERCC1화TS대예측채용오사리박화5-Fu연합화료위암환자화료료효적작용。방법검색납입5편（종2008년도2013년）국제화국내유관ERCC1화TS관우예측5-Fu화오사리박대우위암화료료효적문헌，응용수궤효응모형화고정효응모형진행종합적정량분석，연건위RevMan5．0。결과 ERCC1대채용5-Fu화오사리박연합화료적위암환자화료료효적RR치위0．74，95％CI위0．58-0．95。 TS대채용5-Fu화오사리박연합화료적위암환자화료료효적RR치위7．55，95％CI위4．47-12．76。결론 ERCC1음성적위암환자，채용5-Fu화오사리박화료적료효경호。TS양성적위암환자，채용5-Fu화오사리박화료적료효경호。
Objective To study the efficacy of ERCC 1 and TS in gastric cancer patients who received chemotherapy of 5-Fu and oxaliplatin.Methods 5 papers(from 2008 to 2013) of international and domestic study about ERCC 1 and TS on the prediction of 5-Fu and oxaliplatin for gastric cancer were collected and analyzed with RevMan 5.0.Random effect model and fixed effect model were applied for data processing .Results The RR value of ERCC1 in gastric cancer patients who received 5-Fu and oxaliplatin was 0.74,95%of CI was 0.58-0.95.The RR value of TS in gastric cancer patients who received 5-Fu and oxaliplatin was 7.55,95%of CI was 4.47-12.76.Conclusion 5-Fu and oxaliplatin for ERCC1 negative gastric cancer patients has good curative effects .5-Fu and oxaliplatin for TS positive gastric cancer patients has better curative effects .