CAJ | 학술논문

目的：探讨B7-H3和B7-H4基因突变在鼻咽癌中的表达及临床意义。方法以60例鼻咽癌标本作为病例组，以30例正常子鼻咽部组织作为对照组，应用免疫组织化学技术，检测两组中B7-H3和B7-H4的表达。结果 B7-H3和B7-H4在鼻咽癌组织中阳性率均明显高于正常鼻咽组织，差异均有显著统计学意义（P＜0．01）；Ⅲ＋Ⅳ期及淋巴结转移患者B7-H3和B7-H4阳性率分别明显高于Ⅰ＋Ⅱ期、无淋巴结转移患者，差异有明显的统计学意义（ P＜0．05）。结论 B7-H3和B7-H4与鼻咽癌发生和发展密切相关。
목적：탐토B7-H3화B7-H4기인돌변재비인암중적표체급림상의의。방법이60례비인암표본작위병례조，이30례정상자비인부조직작위대조조，응용면역조직화학기술，검측량조중B7-H3화B7-H4적표체。결과 B7-H3화B7-H4재비인암조직중양성솔균명현고우정상비인조직，차이균유현저통계학의의（P＜0．01）；Ⅲ＋Ⅳ기급림파결전이환자B7-H3화B7-H4양성솔분별명현고우Ⅰ＋Ⅱ기、무림파결전이환자，차이유명현적통계학의의（ P＜0．05）。결론 B7-H3화B7-H4여비인암발생화발전밀절상관。
Objective To study the expression and clinical significance of B 7-H3 and B7-H4 in nasopharyngeal carcino-ma.Methods 60 cases of endometrial carcinoma was the case group ,and 70 cases of normal endometrial was the control group . The expressions of B7-H3 and B7-H4 in the 2 groups were analyzed by immunohistochemisty .Results The positive rates of B7-H3 and B7-H4 in nasopharyngeal carcinoma were significantly higher than those of normal nasopharyngeal tissues ,the differences were statistically significant ( P<0.01);positive rates of B7-H3 and B7-H4 in stage Ⅲ and Ⅳ and lymph node metastasis pa-tients were significantly higher than those of stage ⅠandⅡand without lymph node metastasis patients ,the differences were sta-tistically significant (P<0.05).Conclusion B7-H3 and B7-H4 are closely related with the carcinogenesis and progression of nasopharyngeal carcinoma .