实用癌症杂志
實用癌癥雜誌
실용암증잡지
THE PRACTICAL JOURNAL OF CANCER
2014年
6期
614-616
,共3页
宫颈癌%ABCG2%CD133
宮頸癌%ABCG2%CD133
궁경암%ABCG2%CD133
Cervical cancer%ABCG2%CD133
目的：探讨宫颈癌组织中ABCG2与CD133的表达对预后的影响。方法将200例宫颈癌病患设为实验组，同期收治的100例宫颈内瘤变患者和100例正常患者分别作为对照A组和作对照B组，统计比较3组患者宫颈病变组织中ABCG2与CD133表达水平，并统计实验组3、12、24个月生存期及预后情况。结果3组患者标本ABCG2、CD133阳性表达率分别为：实验组69．5％、67．0％，对照A组33．0％、32．0％，对照B组18．0％、16．0％，组间差异有统计学意义（P＜0．05）。除生存期3个月ABCG2或CD133的表达阳性组与阴性组组间差异无统计学意义外（P＞0．05），12个月、24个月ABCG2或CD133的表达阳性组与阴性组组间差异均有统计学意义（P＜0．05）。随着阳性程度增加，远期生存率降低，结果有统计学意义（ P＜0．05）。结论宫颈癌组织中ABCG2或CD133的表达阳性可影响患者预后生存率，随着阳性表达程度增加，远期生存率降低。
目的：探討宮頸癌組織中ABCG2與CD133的錶達對預後的影響。方法將200例宮頸癌病患設為實驗組，同期收治的100例宮頸內瘤變患者和100例正常患者分彆作為對照A組和作對照B組，統計比較3組患者宮頸病變組織中ABCG2與CD133錶達水平，併統計實驗組3、12、24箇月生存期及預後情況。結果3組患者標本ABCG2、CD133暘性錶達率分彆為：實驗組69．5％、67．0％，對照A組33．0％、32．0％，對照B組18．0％、16．0％，組間差異有統計學意義（P＜0．05）。除生存期3箇月ABCG2或CD133的錶達暘性組與陰性組組間差異無統計學意義外（P＞0．05），12箇月、24箇月ABCG2或CD133的錶達暘性組與陰性組組間差異均有統計學意義（P＜0．05）。隨著暘性程度增加，遠期生存率降低，結果有統計學意義（ P＜0．05）。結論宮頸癌組織中ABCG2或CD133的錶達暘性可影響患者預後生存率，隨著暘性錶達程度增加，遠期生存率降低。
목적：탐토궁경암조직중ABCG2여CD133적표체대예후적영향。방법장200례궁경암병환설위실험조，동기수치적100례궁경내류변환자화100례정상환자분별작위대조A조화작대조B조，통계비교3조환자궁경병변조직중ABCG2여CD133표체수평，병통계실험조3、12、24개월생존기급예후정황。결과3조환자표본ABCG2、CD133양성표체솔분별위：실험조69．5％、67．0％，대조A조33．0％、32．0％，대조B조18．0％、16．0％，조간차이유통계학의의（P＜0．05）。제생존기3개월ABCG2혹CD133적표체양성조여음성조조간차이무통계학의의외（P＞0．05），12개월、24개월ABCG2혹CD133적표체양성조여음성조조간차이균유통계학의의（P＜0．05）。수착양성정도증가，원기생존솔강저，결과유통계학의의（ P＜0．05）。결론궁경암조직중ABCG2혹CD133적표체양성가영향환자예후생존솔，수착양성표체정도증가，원기생존솔강저。
Objective To investigate the effect of expression of ABCG 2 and CD133 on the prognosis of cervical cancer . Methods 200 cases of cervical cancer patients was the experimental group ,and 100 cases of cervical neoplasia patients and 100 normal patients were group A and group B .The expression of ABCG2 and CD133 in the 3 groups were compared ,and 3-,12-,24-month survival and prognosis of the experimental group were recorded .Results Positive expression rates of ABCG2,CD133 were as follows:69.5%,67.0% in the experimental group ,33.0%,32.0% in the control group A ,18.0%,16.0% in the control group B,and there were statistically significant differences between groups (P<0.05).The 3-month expression of ABCG2 or CD133 positive and negative groups had no significant difference (P>0.05),but 12-month,24-month expression of ABCG2 or CD133 positive and negative groups had significant difference (P<0.05).With the increase of positive degree ,the long-term sur-vival reduced,the results were statistically significant (P<0.05).Conclusion Positive expression of ABCG2 or CD133 may af-fect survival prognosis in cervical cancer ,with the increase of positive expression ,long-term survival is reduced .
