CAJ | 학술논문

目的：观察KKAy糖尿病小鼠的血糖、血脂变化，探讨益气养阴散结中药方对其糖脂代谢的影响。方法：选取雄性12周龄KKAy小鼠，将其随机分为模型组及中药组，同周龄雄性C57BL/6J小鼠为正常组。分别给药，中药组灌服益气养阴散结中药复方，模型组及正常组灌服等量蒸馏水，定期检测小鼠体重、血糖值，并分别于实验的第4、8、12周处死各组小鼠，检测三酰甘油（TG）、胆固醇（TC）、低密度脂蛋白胆固醇（LDL）、高密度脂蛋白胆固醇（HDL）等血脂指标。结果：KKAy小鼠的血糖、血脂水平在初期呈不断上升趋势，随着周龄的增长，血糖血脂有所下降，但仍显著高于正常组，益气养阴散结中药复方干预的小鼠血糖血脂水平有所回落。结论：KKAy小鼠存在明显的血脂异常，益气养阴散结中药复方可有效改善血脂异常情况，延缓糖尿病并发症的发生发展。
목적：관찰KKAy당뇨병소서적혈당、혈지변화，탐토익기양음산결중약방대기당지대사적영향。방법：선취웅성12주령KKAy소서，장기수궤분위모형조급중약조，동주령웅성C57BL/6J소서위정상조。분별급약，중약조관복익기양음산결중약복방，모형조급정상조관복등량증류수，정기검측소서체중、혈당치，병분별우실험적제4、8、12주처사각조소서，검측삼선감유（TG）、담고순（TC）、저밀도지단백담고순（LDL）、고밀도지단백담고순（HDL）등혈지지표。결과：KKAy소서적혈당、혈지수평재초기정불단상승추세，수착주령적증장，혈당혈지유소하강，단잉현저고우정상조，익기양음산결중약복방간예적소서혈당혈지수평유소회락。결론：KKAy소서존재명현적혈지이상，익기양음산결중약복방가유효개선혈지이상정황，연완당뇨병병발증적발생발전。
Objective:To observe the glucose and lipid metabolism in KKAy mice with type 2 diabetes and explore the effects of Yiqi Yangyin Sanjie herbal compound on dyslipidemia.Methods:The 12 -week-old male KKAy mice were randomly divided into model group and TCMgroup,and the same age of male C57BL/6J mice were chose as the normal group.The rats in different groups were trea-ted with relevant medicinal respectively by intragastrical method,as the TCM group were fed with Yiqi Yangyin Sanjie herbal compound, and the model group and normal group applied distilled water.The change of body weight and fasting blood glucose (FBG)were detec-ted.The levels of triglyceride (TG),cholesterol (TC),low-density lipoprotein cholesterol (LDL),high density lipoprotein cholesterol (HDL)were detected after mice were sacrificed respectively at the end of 4th,8th and 12th weeks.Results:In model group,the levels of blood glucose and lipid levels showed a rising trend in the initial stage;with the weekly growth,the levels declined,but still signifi-cantly higher than that of the normal group.After the intervention of Yiqi Yangyin Sanjie herbal compound,blood glucose and lipid levels in mice had dropped slightly.Conclusion:There are significant dyslipidemia in KKAy mice,and Yiqi Yangyin Sanjie herbal compound can correct dyslipidemia effectively,and furthermore delay the development of diabetes complications.