CAJ | 학술논문

目的：观察前列地尔注射液联合百令胶囊对急性肾损伤的疗效并探讨其作用机制。方法：将436例急性肾损伤患者随机分为前列地尔组、百令胶囊组、联合治疗组，在给予一般治疗的基础上分别给予前列地尔注射液、百令胶囊及联合治疗，疗程4周，于治疗前后测尿微量白蛋白排泄率、血清肌酐、尿素、胱抑素C等。结果：与单用前列地尔注射液或百令胶囊比较，联合治疗使尿微量白蛋白排泄率、肌酐、尿素、胱抑素C进一步下降（P＜0.05）。结论：前列地尔注射液联合百令胶囊对急性肾损伤的疗效可靠，且较单用其中一种药物具有更强的肾脏保护作用。
목적：관찰전렬지이주사액연합백령효낭대급성신손상적료효병탐토기작용궤제。방법：장436례급성신손상환자수궤분위전렬지이조、백령효낭조、연합치료조，재급여일반치료적기출상분별급여전렬지이주사액、백령효낭급연합치료，료정4주，우치료전후측뇨미량백단백배설솔、혈청기항、뇨소、광억소C등。결과：여단용전렬지이주사액혹백령효낭비교，연합치료사뇨미량백단백배설솔、기항、뇨소、광억소C진일보하강（P＜0.05）。결론：전렬지이주사액연합백령효낭대급성신손상적료효가고，차교단용기중일충약물구유경강적신장보호작용。
Objective:To observe the therapeutic effect of Alprostadil injection combined with Bailing capsule on patients with acute kidney injury and explore its mechanism of action.Methods:Four hundred and thirty six cases of acute kidney injury were randomly di-vided into alprostadil group,bailing capsule group,combined treatment group.Except from the routine treatment,patients in the three groups were respectively given Alprostadil Injection,bailing capsule and the combined treatment for 4 weeks.The levels of urinary albu-min excretion rate,serum creatinine,urea,cystatin C before and after treatment were measured.Results:Compared with the only appli-cation of Alprostadil injection or corbrin capsule,the combination therapy further decreased the levels of the urinary albumin excretion rate,creatinine,urea,Cystatin C (P<0.05).Conclusion:Alprostadil injection combined with Bailing capsule is effective for acute kid-ney injury is reliable,and has stronger renal protective effect than the single use of one drug.