世界中医药
世界中醫藥
세계중의약
WORLD CHINESE MEDICINE
2014年
6期
717-721
,共5页
吴志奎%张新华%方素萍%王文娟%王蕾%李敏%王荣新%刘咏梅%柴立民%张冲%刘莉%程艳玲%褚娜利
吳誌奎%張新華%方素萍%王文娟%王蕾%李敏%王榮新%劉詠梅%柴立民%張遲%劉莉%程豔玲%褚娜利
오지규%장신화%방소평%왕문연%왕뢰%리민%왕영신%류영매%시립민%장충%류리%정염령%저나리
肾藏精生髓%髓生血%地中海贫血%临床%核心病机%益髓生血颗粒
腎藏精生髓%髓生血%地中海貧血%臨床%覈心病機%益髓生血顆粒
신장정생수%수생혈%지중해빈혈%림상%핵심병궤%익수생혈과립
“Kidney produces marrow,and marrow produces blood”%Thalassemia%Clinical practice%Core pathogenesis%Yisuish-engxue Granule
地中海贫血是因先天性基因缺陷致使珠蛋白合成障碍引起的一种遗传性血液病，也叫珠蛋白合成障碍性贫血。它是世界上发病率高、危害最大的单基因遗传病，至今尚无有效的治疗方法。中国中医科学院广安门医院根据肾藏精生髓、髓生血理论，在广西高发区，用补肾益髓法治疗地中海贫血600余例，取得了肯定疗效。论文探讨了中药治疗地中海贫血的证治规律，总结了近30年的临床实践，提出了中医治疗地中海贫血的理论基础和中医核心病机假说，形成了系统的理论与有效治法。依托多项国家基金，从整体效应、基因突变与疗效关系、骨髓有效造血、红细胞结构与功能、调控珠蛋白mRNA表达等不同层面，探讨了中药治疗地中海贫血疗效特点和作用靶点的分子机制，使中药治疗地中海贫血整体水平达到新的高度。研究结果将从一个侧面揭示“肾藏精”及“与肾相关”疾病的内在关系。从“肾”论治地中海贫血的临床与基础研究成果，为阐释“肾藏精”脏象理论的科学内涵提供了有说服力的证据。
地中海貧血是因先天性基因缺陷緻使珠蛋白閤成障礙引起的一種遺傳性血液病，也叫珠蛋白閤成障礙性貧血。它是世界上髮病率高、危害最大的單基因遺傳病，至今尚無有效的治療方法。中國中醫科學院廣安門醫院根據腎藏精生髓、髓生血理論，在廣西高髮區，用補腎益髓法治療地中海貧血600餘例，取得瞭肯定療效。論文探討瞭中藥治療地中海貧血的證治規律，總結瞭近30年的臨床實踐，提齣瞭中醫治療地中海貧血的理論基礎和中醫覈心病機假說，形成瞭繫統的理論與有效治法。依託多項國傢基金，從整體效應、基因突變與療效關繫、骨髓有效造血、紅細胞結構與功能、調控珠蛋白mRNA錶達等不同層麵，探討瞭中藥治療地中海貧血療效特點和作用靶點的分子機製，使中藥治療地中海貧血整體水平達到新的高度。研究結果將從一箇側麵揭示“腎藏精”及“與腎相關”疾病的內在關繫。從“腎”論治地中海貧血的臨床與基礎研究成果，為闡釋“腎藏精”髒象理論的科學內涵提供瞭有說服力的證據。
지중해빈혈시인선천성기인결함치사주단백합성장애인기적일충유전성혈액병，야규주단백합성장애성빈혈。타시세계상발병솔고、위해최대적단기인유전병，지금상무유효적치료방법。중국중의과학원엄안문의원근거신장정생수、수생혈이론，재엄서고발구，용보신익수법치료지중해빈혈600여례，취득료긍정료효。논문탐토료중약치료지중해빈혈적증치규률，총결료근30년적림상실천，제출료중의치료지중해빈혈적이론기출화중의핵심병궤가설，형성료계통적이론여유효치법。의탁다항국가기금，종정체효응、기인돌변여료효관계、골수유효조혈、홍세포결구여공능、조공주단백mRNA표체등불동층면，탐토료중약치료지중해빈혈료효특점화작용파점적분자궤제，사중약치료지중해빈혈정체수평체도신적고도。연구결과장종일개측면게시“신장정”급“여신상관”질병적내재관계。종“신”론치지중해빈혈적림상여기출연구성과，위천석“신장정”장상이론적과학내함제공료유설복력적증거。
Thalassemia is a common and hazard monogenic inherited hematologic disease with high morbidity in the world,which is caused by gene mutation or defect in the synthesis of one or more of the hemoglobin chains.So far,there has been found no special effec-tive measures for the treatment of thalassemia.According to the traditional Chinese medicine theory“kidney generates marrow,and mar-row generates blood”,Prof.Wu treated 600 thalassemia patients in Guangxi where the disease frequently occurs with the method of toni-fying kidney and benefiting marrow and gained positive effects.The paper summarized the clinical practices of last 30 years,discussed the regular pattern about the treatment by traditional Chinese medicine on thalassemia,and thus put forward the hypothesis of TCM core pathogenesis of thalassemia as well as the possibility of treatment according to the core pathogenesis based on the basic theory and thera-peutic principles of thalassemia.The clinical practice and intensive mechanism study on the effects further proved the effectiveness of the TCM theory “kidney produces marrow,and marrow produces blood”in curing thalassemia.Depending on many national funds,we have studied the molecular mechanism of treating thalassemia by traditional Chinese medicine,including the overall effects,the relationship be-tween clinical effect and gene mutation,bone marrow hematopoiesis,the structure and function of red blood cells as well as RNA expres-sion of related globins and thus achieved a new level for curing thalassemia by Chinese traditional medicine .The clinical and basic re-search works revealed from another aspect the internal relationship between the theory”kidney produces marrow”and diseases related to kidney,and thus provided powerful proof to clarify the scientific essence for the theory “kidney produces marrow”.
