CAJ | 학술논문

目的：探讨高海拔地区高龄患者全髋关节置换术行蛛网膜下腔注射0.375%布比卡因的半数有效剂量(ED50)及95%有效剂量(ED95)。方法拟在腰-硬联合阻滞下行全髋关节置换术的高海拔高龄患者23例,年龄73~99岁,ASA Ⅱ或Ⅲ级,采用序贯法进行研究,蛛网膜下腔注射等比重0.375%布比卡因,初始剂量为3.0 mg,相邻剂量比值为0.8,计算0.375%等比重布比卡因的ED50、ED95及其95%可信区间(CI)。结果其中20例成功完成测试,得到布比卡因的 ED50(95%CI)、ED95(95%CI)分别为4.81(3.98~5.81)mg、7.29(6.03~8.81)mg。结论蛛网膜下腔注射0.375%等比重布比卡因7.5 mg 能满足高海拔绝大多数高龄患者接受全髋关节置换手术的麻醉需要。
목적：탐토고해발지구고령환자전관관절치환술행주망막하강주사0.375%포비잡인적반수유효제량(ED50)급95%유효제량(ED95)。방법의재요-경연합조체하행전관관절치환술적고해발고령환자23례,년령73~99세,ASA Ⅱ혹Ⅲ급,채용서관법진행연구,주망막하강주사등비중0.375%포비잡인,초시제량위3.0 mg,상린제량비치위0.8,계산0.375%등비중포비잡인적ED50、ED95급기95%가신구간(CI)。결과기중20례성공완성측시,득도포비잡인적 ED50(95%CI)、ED95(95%CI)분별위4.81(3.98~5.81)mg、7.29(6.03~8.81)mg。결론주망막하강주사0.375%등비중포비잡인7.5 mg 능만족고해발절대다수고령환자접수전관관절치환수술적마취수요。
Objective To investigate the ED50 and ED9 5 of subarachnoid 0.375% bupivacaine in elderly patients undergoing elective total hip arthroplasty (THA ) in high altitude area. Methods Twenty-three elderly patients,aged 73-99 years old,ASA Ⅱ or Ⅲ,selected for total hip ar-throplasty (THA)under combined spinal-epidural (CSE)anesthesia were enrolled in this study and predose of 3.0 mg,0.375% (m/v)bupivacaine administered in subarachnoid,following dosage in-creased by ratio of 0.8.Calculate the ED50 and ED9 5 of subarachnoid 0.375% bupivacaine and 95%CI.Results Twenty of 23 underwent the test completely.The ED50 (95%CI)and ED9 5 (95%CI)of 0.375% (m/v)bupivacaine were 4.81 mg (3.98-5.81 )and 7.29 mg (6.03-8.81 ),respectively. Conclusion Subarachnoid 0.375% bupivacaine (7.5 mg)can be used effectively and safely in elderly patients undergoing total hip arthroplasty in high altitudes area.