临床肿瘤学杂志
臨床腫瘤學雜誌
림상종류학잡지
CHINESE CLINICAL ONCOLOGY
2014年
6期
564-568
,共5页
邹志伟(综述)%刘求真(审校)
鄒誌偉(綜述)%劉求真(審校)
추지위(종술)%류구진(심교)
肺癌%细胞信号转导通路%分子靶向治疗
肺癌%細胞信號轉導通路%分子靶嚮治療
폐암%세포신호전도통로%분자파향치료
Lung cancer%Cell signal transduction pathway%Molecule targeted therapy
信号转导是各类信号通过细胞膜或胞内信使分子引起细胞基因表达改变的过程。因此，当细胞信号转导过程发生障碍或异常，必然会导致细胞生长、分化、代谢及生物学特征异常，从而引起各种疾病甚至肿瘤的发生。目前已知与肺癌相关的细胞信号转导通路有Wnt、Notch、酪氨酸激酶和Hedgehog信号转导通路。现将近年来的研究进展作一综述。
信號轉導是各類信號通過細胞膜或胞內信使分子引起細胞基因錶達改變的過程。因此，噹細胞信號轉導過程髮生障礙或異常，必然會導緻細胞生長、分化、代謝及生物學特徵異常，從而引起各種疾病甚至腫瘤的髮生。目前已知與肺癌相關的細胞信號轉導通路有Wnt、Notch、酪氨痠激酶和Hedgehog信號轉導通路。現將近年來的研究進展作一綜述。
신호전도시각류신호통과세포막혹포내신사분자인기세포기인표체개변적과정。인차，당세포신호전도과정발생장애혹이상，필연회도치세포생장、분화、대사급생물학특정이상，종이인기각충질병심지종류적발생。목전이지여폐암상관적세포신호전도통로유Wnt、Notch、락안산격매화Hedgehog신호전도통로。현장근년래적연구진전작일종술。
Signal transduction is a process causing changes of gene expression in cells by signals through the cell membrane or intracellular messenger molecule. Therefore, cell signal transduction disorder or abnormality, will inevitably lead to cell growth, differ-entiation, metabolism and biological abnormalities, resulting in various diseases and even cancer. The cell signal transduction pathways associated with lung cancer include Wnt, Notch, tyrosine kinase and Hedgehog signal transduction pathway. This article makes a review on recent research.
