CAJ | 학술논문

目的：研究不同临床类型的口腔扁平苔藓（OLP）中细胞信号传导和转录激活因子3（STAT3）的表达及意义。方法：采用免疫组织化学方法分别检测10例正常口腔黏膜组织，29例非糜烂型OLP、16例充血糜烂型OLP损害中STAT3的表达。结果：STAT3阳性表达分布于细胞质和细胞核内。正常口腔黏膜、非糜烂型OLP、糜烂型OLP上皮层中STAT3阳性表达率分别为30．00％（3/10）、75．86％（22/29）、93．75％（15/16）；固有层中分别为0％（0/10）、65．52％（19/29）、100．00％（16/16）；三种类型上皮层两两之间相比，差异有统计学意义（P＜0．05）；固有层两两之间相比，只有非糜烂型OLP和糜烂型OLP之间差异没有统计学意义（P＞0．05）。结论：STAT3与OLP上皮层的炎症进程密切相关，对STAT3表达的研究将有助于进一步探究OLP的发病机制和早期临床诊疗。
목적：연구불동림상류형적구강편평태선（OLP）중세포신호전도화전록격활인자3（STAT3）적표체급의의。방법：채용면역조직화학방법분별검측10례정상구강점막조직，29례비미란형OLP、16례충혈미란형OLP손해중STAT3적표체。결과：STAT3양성표체분포우세포질화세포핵내。정상구강점막、비미란형OLP、미란형OLP상피층중STAT3양성표체솔분별위30．00％（3/10）、75．86％（22/29）、93．75％（15/16）；고유층중분별위0％（0/10）、65．52％（19/29）、100．00％（16/16）；삼충류형상피층량량지간상비，차이유통계학의의（P＜0．05）；고유층량량지간상비，지유비미란형OLP화미란형OLP지간차이몰유통계학의의（P＞0．05）。결론：STAT3여OLP상피층적염증진정밀절상관，대STAT3표체적연구장유조우진일보탐구OLP적발병궤제화조기림상진료。
Objective:To study the expression and significance of STAT3 in Oral Lichen Planus (OLP) of different clinical types. Method:The immunohistochemical assay was used to detect 10 cases of normal oral mucosa,30 patients with non-erosive OLP and 20 patients with erosive OLP of STAT3 protein expression in the lesions. Result:STAT3 was expressed in the cell cytoplasm,and nuclear expression was also found in some cells in OLP.In the cases of normal oral mucosa,non-erosive and erosive OLP,the rate of STAT3 expression in epithelial layer was 30 %(3/10)、75.86 %(22/29)、93.75 %(15/16),respectively;in lamina propria,0 %(0/10)、65.52 %(19/29)、100 %(16/16),respectively;There were statis-tical significances of STAT3 expression between normal oral mucosa and non-erosive OLP as well as erosive OLP in epithe-lial layer (P<0.05),while no statistical significances of STAT3 expression were found only between non-erosive and erosive OLP in lamina propria (P >0.05). Conclusion:The over-expression of STAT3 played an important role in the inflammation progression of the OLP's epithelium,and the study of STAT3 expression was useful for detection of the pathogenesis and ear-ly diagnosis of OLP.