临床误诊误治
臨床誤診誤治
림상오진오치
CLINICAL MISDIAGNOSIS & MISTHERAPY
2014年
6期
91-95
,共5页
路甲鹏%郭青青%赵玉凤%王斌
路甲鵬%郭青青%趙玉鳳%王斌
로갑붕%곽청청%조옥봉%왕빈
心肌梗死%中西医结合疗法%随机对照试验%meta分析
心肌梗死%中西醫結閤療法%隨機對照試驗%meta分析
심기경사%중서의결합요법%수궤대조시험%meta분석
Myocardial infarction%TCM WM therapy%Randomized controlled trial%Meta-analysis
目的综合评价中西医结合治疗急性心肌梗死( acute myocardial infarction, AMI)的临床效果。方法检索中国期刊全文数据库、中国科技期刊全文数据库、万方数据库、Pubmed、EMbase数据库1991年1月-2014年1月发表的关于中西医结合治疗AMI的文献,并采用系统评价和meta分析方法进行分析。结果本研究最终纳入随机对照试验15项共998例AMI。 meta分析显示,中西医结合治疗组的临床效果[合并相对危险度( relative risk, RR)=1.11,95%可信区间(confidence interval, CI)：1.01~1.21,P=0.03]及血管再通率(合并RR=1.11,95%CI：1.01~1.21,P=0.03)均显著优于单纯西医治疗组(对照组)；中西医结合治疗组心排血量、左室射血分数及肌酸激酶同工酶水平显著优于对照组(P<0.01),且并发症发生率显著低于对照组(合并RR=0.66,95%CI：0.47~0.93,P<0.001)。结论中西医结合治疗AMI效果优于单纯西医治疗且不良反应发生率低。
目的綜閤評價中西醫結閤治療急性心肌梗死( acute myocardial infarction, AMI)的臨床效果。方法檢索中國期刊全文數據庫、中國科技期刊全文數據庫、萬方數據庫、Pubmed、EMbase數據庫1991年1月-2014年1月髮錶的關于中西醫結閤治療AMI的文獻,併採用繫統評價和meta分析方法進行分析。結果本研究最終納入隨機對照試驗15項共998例AMI。 meta分析顯示,中西醫結閤治療組的臨床效果[閤併相對危險度( relative risk, RR)=1.11,95%可信區間(confidence interval, CI)：1.01~1.21,P=0.03]及血管再通率(閤併RR=1.11,95%CI：1.01~1.21,P=0.03)均顯著優于單純西醫治療組(對照組)；中西醫結閤治療組心排血量、左室射血分數及肌痠激酶同工酶水平顯著優于對照組(P<0.01),且併髮癥髮生率顯著低于對照組(閤併RR=0.66,95%CI：0.47~0.93,P<0.001)。結論中西醫結閤治療AMI效果優于單純西醫治療且不良反應髮生率低。
목적종합평개중서의결합치료급성심기경사( acute myocardial infarction, AMI)적림상효과。방법검색중국기간전문수거고、중국과기기간전문수거고、만방수거고、Pubmed、EMbase수거고1991년1월-2014년1월발표적관우중서의결합치료AMI적문헌,병채용계통평개화meta분석방법진행분석。결과본연구최종납입수궤대조시험15항공998례AMI。 meta분석현시,중서의결합치료조적림상효과[합병상대위험도( relative risk, RR)=1.11,95%가신구간(confidence interval, CI)：1.01~1.21,P=0.03]급혈관재통솔(합병RR=1.11,95%CI：1.01~1.21,P=0.03)균현저우우단순서의치료조(대조조)；중서의결합치료조심배혈량、좌실사혈분수급기산격매동공매수평현저우우대조조(P<0.01),차병발증발생솔현저저우대조조(합병RR=0.66,95%CI：0.47~0.93,P<0.001)。결론중서의결합치료AMI효과우우단순서의치료차불량반응발생솔저。
Objective To comprehensively evaluate the effect of traditional Chinese medicine combined with Western medicine in treatment of acute myocardial infarction ( AMI) . Methods Relevant literature of traditional Chinese medicine combined with Western medicine in treatment of AMI published between January 1999 and January 2014 was retrieved from databases of CNKI, VIP, Wanfang, Pubmed and EMbase, and system assessment and meta-analysis were performed. Results A total of 15 RCTs ( randomized controlled trials) including 998 AMI patients were recruited in this study, The meta-analy-sis result showed that the clinical effect (combined RR=1. 11, 95% CI:1. 01-1. 21, P=0.03) and revascularization rate (combined RR=1.11, 95% CI:1. 01-1. 21, P=0. 03) by traditional Chinese medicine combined with Western medicine in treatment of AMI was significantly better than those by western medicine;values of cardiac output, ventriculus sinister of e-jection fraction and creatine kinase isoenzyme by traditional Chinese medicine combined with Western medicine was signifi-cantly better than those by Western medicine (P<0. 01), and the incidence rate of complications was significantly lower than that by Western medicine treatment group (combined RR=0. 66, 95% CI:0. 47-0. 93, P<0. 001). Conclusion Tradi-tional Chinese medicine combined with Western medicine in treatment of acute myocardial infarction has better curative effect and lower incidence rate of complications, compared with those by only Western medicine treatment.
