CAJ | 학술논문

目的：探讨利奈唑胺治疗儿童重症革兰阳性菌感染的临床效果。方法回顾性分析以经验用药治疗无效而根据痰培养及药敏试验结果换用利奈唑胺治疗的重症革兰阳性菌感染患儿的临床资料。结果24例重症革兰阳性菌感染患儿经静脉滴注利奈唑胺（10 mg/kg，q8 h），疗程10~14 d，均显效或好转。结论在经验用药治疗无效时，选择利奈唑胺单用或联合其他药物治疗儿童重症革兰阳性菌感染可取得满意的临床效果。
목적：탐토리내서알치료인동중증혁란양성균감염적림상효과。방법회고성분석이경험용약치료무효이근거담배양급약민시험결과환용리내서알치료적중증혁란양성균감염환인적림상자료。결과24례중증혁란양성균감염환인경정맥적주리내서알（10 mg/kg，q8 h），료정10~14 d，균현효혹호전。결론재경험용약치료무효시，선택리내서알단용혹연합기타약물치료인동중증혁란양성균감염가취득만의적림상효과。
Objective To investigate the clinical effect of linezolid on severe Gram-positive bacteria infection in chil-dren. Methods The retrospective analysis was performed in the clinical cases of severe Gram-positive bacteria infection which were insensitive to drugs selected from experience but sensitive to linezolid according to sputum culture and sensitivity test. Re-sults Twenty-four children with severe Gram-positive bacterial infections were treated with linezolid by intravenous infusion (10 mg/kg, q8h) for 10-14 days. All of them were markedly improved. Conclusions When drugs selected from experiences are ineffective, linezolid or in combination with other drugs is a good choice in the treatment of severe Gram-positive bacterial in-fections.