CAJ | 학술논문

目的：了解儿童侵袭性肺炎链球菌疾病（IPD）的临床特点及侵袭性肺炎链球菌（Sp）的耐药情况。方法回顾性分析2009年至2012年收治的54例IPD患儿临床资料以及54株侵袭性Sp的药敏结果。结果54例IPD患儿中男女比为1.35∶1，以<2岁的婴幼儿居多，夏季起病少；临床诊断以脓毒血症为主，其次为脑膜炎；患儿均有发热，且以中高热为主；44例出现白细胞计数增高，42例出现CRP增高；β-内酰胺类抗生素使用最多，其次为万古霉素。侵袭性Sp对青霉素的不敏感率达59.26%，多重耐药率高达96.30%。结论 IPD发病存在一定季节差异；临床表现多样，脓毒血症最常见；侵袭性Sp对青霉素耐药性较高。
목적：료해인동침습성폐염련구균질병（IPD）적림상특점급침습성폐염련구균（Sp）적내약정황。방법회고성분석2009년지2012년수치적54례IPD환인림상자료이급54주침습성Sp적약민결과。결과54례IPD환인중남녀비위1.35∶1，이<2세적영유인거다，하계기병소；림상진단이농독혈증위주，기차위뇌막염；환인균유발열，차이중고열위주；44례출현백세포계수증고，42례출현CRP증고；β-내선알류항생소사용최다，기차위만고매소。침습성Sp대청매소적불민감솔체59.26%，다중내약솔고체96.30%。결론 IPD발병존재일정계절차이；림상표현다양，농독혈증최상견；침습성Sp대청매소내약성교고。
Objective To investigate the clinical features of invasive pneumococcal disease (IPD) and the antimicrobial susceptibility of invasive Streptococcus pneumoniae (Sp). Methods The clinical features of 54 children with IPD and the antimi-crobial susceptibility of 54 invasive Sp isolates were retrospectively analyzed from 2009 to 2012. Results The ratio of boys to girls in IPD was 1.35:1. Most of the children with IPD were within 2 years old. Few of the children had the onset in summer. Most of the children were diagnosed with septicemia, followed by meningitis. All of the children had middle or high fever. Forty-four children had an increased white blood cell count and 42 children had an increased C-reactive protein.β-lactam antibiotics was most frequently used in clinics, followed by vancomycin. Most of invasive Sp were resistant to penicillin. Multiple drug resis-tance was common in invasive Sp. Conclusions The incidence of IPD has seasonal difference. The clinical manifestations of IPD are diverse, with septicemia being the most common. The resistant rate to penicillin is high in invasive Sp.