CAJ | 학술논문

目的：探讨乙型肝炎病毒（HBV）血清标志物异常新生儿的转归。方法筛选HBV血清标志物异常新生儿28例，其母乙肝表面抗原（HbsAg）、乙肝e抗原（HbeAg）、乙肝核心抗体（HbcAb）均阳性；其中21例新生儿HBsAg、HBeAg、HBcAb均为阳性组成垂直传播组；另7例新生儿HBeAg、HBcAb阳性而HBsAg阴性，组成可疑组。HBV血清标志物检测采用时间分辨免疫荧光法，HBV-DNA采用荧光定量聚合酶链反应。结果可疑组新生儿的血清HBeAg和HBsAg水平均低于垂直传播组，差异均有统计学意义（P<0.05）。可疑组新生儿出生后3个月复检HBeAg水平为（0.55±0.19）PEIU/ml，低于出生后7 d内检测结果[（4.02±2.00）PEIU/ml]，差异有统计学意义（P<0.05）。结论对于HBV血清标志物异常母亲及新生儿，早期干预有积极意义。
목적：탐토을형간염병독（HBV）혈청표지물이상신생인적전귀。방법사선HBV혈청표지물이상신생인28례，기모을간표면항원（HbsAg）、을간e항원（HbeAg）、을간핵심항체（HbcAb）균양성；기중21례신생인HBsAg、HBeAg、HBcAb균위양성조성수직전파조；령7례신생인HBeAg、HBcAb양성이HBsAg음성，조성가의조。HBV혈청표지물검측채용시간분변면역형광법，HBV-DNA채용형광정량취합매련반응。결과가의조신생인적혈청HBeAg화HBsAg수평균저우수직전파조，차이균유통계학의의（P<0.05）。가의조신생인출생후3개월복검HBeAg수평위（0.55±0.19）PEIU/ml，저우출생후7 d내검측결과[（4.02±2.00）PEIU/ml]，차이유통계학의의（P<0.05）。결론대우HBV혈청표지물이상모친급신생인，조기간예유적겁의의。
Objectives To investigate the outcomes of neonatals with abnormal hepatitis B virus (HBV) serological markers. Methods Twenty-eight neonatals who had abnormal HBV serological markers and whose mothers had positive HBsAg, HbeAg and HbcAb were studied. Among them, 21 neonatals who had positive HBsAg, HbeAg and HbcAb were included in vertical transmission group;7 neonatals who had positive HbeAg, HbcAb and negative HBsAg were included in suspicious group. The quantities of HBV serological markers were determined by time-resolved immunofluorometric assay (IFMA) and the level of HBV DNA were measured by fluorescence quantitative PCR (FQ-PCR). Results Serum HBeAg and HBsAg levels in suspi-cious group were lower than those in vertical transmission group (P<0.05). The results showed that HBeAg level (0.55 ± 0.19 PEIU/ml) three months after birth was lower than that (4.02 ± 2.00 PEIU/ml) 7 days after birth in suspicious group (P<0.05). Conclusions Early interference has positive effect in mothers and neonatls with abnormal HBV serological markers.