CAJ | 학술논문

目的：探讨静息状态下遗忘型轻度认知障碍（aMCI）杏仁核功能连接在随访（13．0±2．2）个月前后的纵向变化。方法：纳入经临床确诊的13例aMCI患者，于纳入研究时及随访时接受静息态功能 MRI扫描，使用SPM8软件分析，采用感兴趣区种子体素分析方法，比较杏仁核功能连接前后两次的差异，分析杏仁核功能连接强度变化与神经心理评估结果之间的关系。结果：与基线对比，aMCI 随访后蒙特利尔认知评估量表（MoCA）成绩下降，差异有统计学意义（P＜0．05）。同时与基线相比，aMCI随访后与左侧杏仁核功能连接明显降低的区域有双侧颞中回/枕中回、左侧额中回/前扣带回、左侧楔叶/后扣带回/楔前叶结合部，与右侧杏仁核功能连接明显降低的区域为左侧额中回/前扣带回，然而与右侧杏仁核功能连接明显增强的区域为左侧额上回/额中回。重要的是杏仁核与以上脑区间功能连接的改变与认知能力呈正相关。结论：在aMCI向阿尔茨海默病转化过程中，杏仁核与多个脑区之间出现功能连接异常，可能是评价aMCI 演变的一个潜在的生物学标志。
목적：탐토정식상태하유망형경도인지장애（aMCI）행인핵공능련접재수방（13．0±2．2）개월전후적종향변화。방법：납입경림상학진적13례aMCI환자，우납입연구시급수방시접수정식태공능 MRI소묘，사용SPM8연건분석，채용감흥취구충자체소분석방법，비교행인핵공능련접전후량차적차이，분석행인핵공능련접강도변화여신경심리평고결과지간적관계。결과：여기선대비，aMCI 수방후몽특리이인지평고량표（MoCA）성적하강，차이유통계학의의（P＜0．05）。동시여기선상비，aMCI수방후여좌측행인핵공능련접명현강저적구역유쌍측섭중회/침중회、좌측액중회/전구대회、좌측설협/후구대회/설전협결합부，여우측행인핵공능련접명현강저적구역위좌측액중회/전구대회，연이여우측행인핵공능련접명현증강적구역위좌측액상회/액중회。중요적시행인핵여이상뇌구간공능련접적개변여인지능력정정상관。결론：재aMCI향아이자해묵병전화과정중，행인핵여다개뇌구지간출현공능련접이상，가능시평개aMCI 연변적일개잠재적생물학표지。
Objective:To investigate the longitudinal alteration of the functional connectivity of the amygdala in the rest status of the amnestic mild cognitive impairment (aMCI)subjects during an average period of 13±2.2 months follow-up.Methods:Thirteen aMCI subjects were included and received rest-state functional magnetic resonance imaging examina-tion both at the baseline and 13±2.2 months later.The difference of the functional connectivity of the amygdala between the baseline and follow-up was analyzed by the SPM8 software and the ROI seeding method.The relationship between the neuropsychological tests and the longitudinal alteration of the functional connectivity of the amygdala was studied.Results:Compared with the baseline,the MoCA scores were decreased in the follow-up aMCI subjects and the difference was statis-tically significant (P<0.05).Meanwhile compared with the baseline aMCI subjects,for the left amygdala,a decreased func-tional connectivity was found in several regions,including the bilateral middle temporal/occipital gurus (MTG/MOG),the left middle frontal gyrus/anterior cingulate cortex (MFG/ACC),and the conjunctional region of the left cuneus/posterior cingulate cortex/precuneus (Cun/PCC/Pcu).In the right amygdala of the follow-up aMCI subj ects and compared with base-line,decreased functional connectivity was found in the conjunctional region of the left middle frontal gyrus/anterior cingu-late cortex (MFG/ACC),while increased functional connectivity was found in the conj unctional region of the left superior frontal gyrus/middle frontal gyrus (SFG/MFG).Importantly,the altered functional connectivity between the amygdala and the above mentioned regions was positively correlated with cognitive abilities.Conclusion:The functional connectivity chan-ges between the amygdala and multiple cerebral cortexs might be a potential biomarker for evaluating the progression of aMCI.