CAJ | 학술논문

目的：比较Hyper-CVAD/MA与EPOCH两种方案治疗侵袭性非霍奇金淋巴瘤的临床效果。方法35例侵袭性非霍奇金淋巴瘤初治患者随机分为 Hyper-CVAD/MA 组（17例）与 EPOCH 组（18例），按各自的方案给药，评估其疗效和不良反应。结果 Hyper-CVAD/MA组总有效率为64．71％，EPOCH组总有效率为72．22％。两种方案治疗的患者均出现不同程度骨髓抑制，消化道反应、脱发、神经毒性、黏膜炎等，两种方案的不良反应差异无统计学意义（P＞0．05）。结论 Hyper-CVAD/MA与EPOCH两种方案治疗侵袭性非霍奇金淋巴瘤的临床效果与不良反应相当，两者均为治疗侵袭性淋巴瘤的合理化疗方案。
목적：비교Hyper-CVAD/MA여EPOCH량충방안치료침습성비곽기금림파류적림상효과。방법35례침습성비곽기금림파류초치환자수궤분위 Hyper-CVAD/MA 조（17례）여 EPOCH 조（18례），안각자적방안급약，평고기료효화불량반응。결과 Hyper-CVAD/MA조총유효솔위64．71％，EPOCH조총유효솔위72．22％。량충방안치료적환자균출현불동정도골수억제，소화도반응、탈발、신경독성、점막염등，량충방안적불량반응차이무통계학의의（P＞0．05）。결론 Hyper-CVAD/MA여EPOCH량충방안치료침습성비곽기금림파류적림상효과여불량반응상당，량자균위치료침습성림파류적합이화료방안。
Objective To compare the chemotherapy method between Hyper-CVAD/MA and EPOCH for the treatment on aggressive non-hodgkin's lymphoma.Methods We collected 35 patients with aggressive non-hodgkin's lymphoma in our hospital from May 201 0 to April 201 3,and the patients were divided into the Hyper-CVAD/MA (1 7 cases)and EPOCH(1 8 cases)groups randomly,then they were adminis-tered according to their respective solution,and the efficacy and adverse reactions were evaluated after the therapy.Results The total effec-tive rate in the Hyper-CVAD/MA group was 64.71%,and that in EPOCH chemotherapy group was 72.22%.Two kinds of chemotherapy method in patients had the different degree of bone marrow suppression,gastrointestinal reactions,alopecia,neurotoxicity,mucositis,etc.There was no significant difference in adverse reactions between two chemotherapy methods.Conclusion There is no statistical difference between the Hyper-CVAD/MA and EPOCH in clinic effect and adverse reactions for the treatment on aggressive non-hodgkin's lymphoma;both are the reasonable chemotherapy regimens for the treatment of aggressive lymphoma.