CAJ | 학술논문

目的：探讨女性初诊2型糖尿病（T2 DM）患者血清γ-谷氨酰转肽酶（GGT）水平与多种心血管危险因素之间的相关性。方法160例女性初诊T2DM患者按GGT四分位数分组。比较各组间体质量指数（BMI）、血压、血脂、尿酸（UA）、C反应蛋白（CRP）、血糖、胰岛素等生化指标。结果 GGT水平不同时，BMI、收缩压（SBP）、三酰甘油（TG）、CRP、稳态胰岛素评估模型胰岛素抵抗（HOMA-IR）水平差异有统计学意义（P＜0．05）；GGT与SBP、TG、CRP、HOMA-IR 、UA呈正相关；TG和CRP是GGT的独立危险因素。结论女性T2 DM患者血清GGT与多种心血管危险因素相关，提示其对糖尿病心血管并发症可能有预示作用。
목적：탐토녀성초진2형당뇨병（T2 DM）환자혈청γ-곡안선전태매（GGT）수평여다충심혈관위험인소지간적상관성。방법160례녀성초진T2DM환자안GGT사분위수분조。비교각조간체질량지수（BMI）、혈압、혈지、뇨산（UA）、C반응단백（CRP）、혈당、이도소등생화지표。결과 GGT수평불동시，BMI、수축압（SBP）、삼선감유（TG）、CRP、은태이도소평고모형이도소저항（HOMA-IR）수평차이유통계학의의（P＜0．05）；GGT여SBP、TG、CRP、HOMA-IR 、UA정정상관；TG화CRP시GGT적독립위험인소。결론녀성T2 DM환자혈청GGT여다충심혈관위험인소상관，제시기대당뇨병심혈관병발증가능유예시작용。
Objective To explore the correlation between serum gamma glutamyl transpeptidase(GGT)levels and multiple cardiovas-cular risk factors in female patients with newly diagnosed type 2 diabetes mellitus(T2DM).Methods A total of 1 60 female patients with newly diagnosed T2DMwere assigned into four groups according to quartiles of GGT.Their body mass index(BMI),blood pressure,serum lip-id,uric acid (UA),C-reactive protein(CRP),glucose,insulin and other biochemical indicator were measured and compared.Results BMI, systolic blood pressure (SBP),triglyceride (TG),CRP,homeostasis model of insulin resistance insulin (HOMA-IR)levels had significant difference in different GGT groups(P<0.05);GGT and systolic blood pressure (SBP),TG,CRP,HOMA-IR,UA were positively correlated;high levels of TG and CRP were independent risk factors of GGT.Conclusion Serum GGT is associated with multiple cardiovascular risk factors in female patients with T2DM,suggesting that there is an indicative effect on cardiovascular complications of diabetes.