CAJ | 학술논문

目的：探讨血清、尿游离轻链检测的临床应用。方法利用速率散射比浊法对临床确诊的45例结缔组织病（CTD）及43例多发性骨髓瘤（MM）患者血清和尿液中游离轻链进行测定。结果 CTD组血清与尿κ型轻链含量明显低于κ型MM组（P＜0．05），CTD组血清与尿λ型轻链含量亦明显低于λ型MM组（P＜0．05）；CTD组血清与尿κ/λ比值低于κ型MM组（P＜0．05），高于λ型MM组（P＜0．05）。45例CTD组血清轻链检测无一例表现为κ/λ比值失衡，而43例MM组中有41例表现为比例失衡。结论对免疫球蛋白明显升高的CTD，为了解是否同时存在MM，血清与尿κ、λ及κ/λ比值测定有临床应用价值。
목적：탐토혈청、뇨유리경련검측적림상응용。방법이용속솔산사비탁법대림상학진적45례결체조직병（CTD）급43례다발성골수류（MM）환자혈청화뇨액중유리경련진행측정。결과 CTD조혈청여뇨κ형경련함량명현저우κ형MM조（P＜0．05），CTD조혈청여뇨λ형경련함량역명현저우λ형MM조（P＜0．05）；CTD조혈청여뇨κ/λ비치저우κ형MM조（P＜0．05），고우λ형MM조（P＜0．05）。45례CTD조혈청경련검측무일례표현위κ/λ비치실형，이43례MM조중유41례표현위비례실형。결론대면역구단백명현승고적CTD，위료해시부동시존재MM，혈청여뇨κ、λ급κ/λ비치측정유림상응용개치。
Objective To discuss the clinical application of serum and urine free light chain detection.Methods The levels of free light chain in serum and urine were measured in the cases of connective tissue disease(CTD)and multiple myeloma (MM)by nephelometry. Results The levels of light chainκin serum and urine of CTD patients were lower than those of type κMMpatients(P<0.05).The levels of light chain λin serum and urine of CTD patients were also lower than those of type λMM patients(P<0.05).The serum and urineκ/λratio of CTD patients was lower than that of type κMM patients (P<0.05 ),but higher than that of type λMM patients (P<0.05 ). There was no one ratio imbalance of the serumκ/λin CTD patients,while there were 41 in MM patients.Conclusion For CTD in which im-mune globulin is significantly high,light chain testing can help to understand whether MMexists.The serum and urineκ,λandκ/λratio have value in clinical application.