CAJ | 학술논문

目的：探讨血液灌流在儿童重症过敏性紫癜中应用的临床价值。方法选择60例符合标准的患儿，随机分为常规组和灌流组，常规组使用常规治疗方案，灌流组在此基础上加血液灌流治疗，比较两组临床疗效及血液指标如IgA、CRP、TNF-α、IL-6的变化。结果灌流组的临床症状缓解时间较常规组缩短，差异有统计学意义（P＜0．05）；灌流组的血液指标IgA、CRP、TNF-α、IL-6下降幅度与常规组差异有统计学意义（P＜0．05）。结论血液灌流在重症过敏性紫癜急性期可以短时间内较快清除炎症介质、免疫复合物等炎症因子，从而快速地缓解患儿病情。
목적：탐토혈액관류재인동중증과민성자전중응용적림상개치。방법선택60례부합표준적환인，수궤분위상규조화관류조，상규조사용상규치료방안，관류조재차기출상가혈액관류치료，비교량조림상료효급혈액지표여IgA、CRP、TNF-α、IL-6적변화。결과관류조적림상증상완해시간교상규조축단，차이유통계학의의（P＜0．05）；관류조적혈액지표IgA、CRP、TNF-α、IL-6하강폭도여상규조차이유통계학의의（P＜0．05）。결론혈액관류재중증과민성자전급성기가이단시간내교쾌청제염증개질、면역복합물등염증인자，종이쾌속지완해환인병정。
Objective To investigate the hemoperfusion in the treatment of severe henoch-schonlein purpura in children.Methods Choose 60 cases in line with the standard of severe henoch-schonlein purpura,and divide into the normal group and the control group.Normal group using conventional treatment,control group on the basis of conventional treatment combined with hemoperfusion treatment,contrast the clinical effect and blood indexes such as IgA,CRP,TNF-αand IL-6,the change of them in the two groups.Results Control group with he-moperfusion showed relief in clinical symptoms shortened time when compared with normal group (P<0.05 ),the blood indexes of control group,such as IgA,CRP,TNF-αand IL-6,compared to the normal group decreased significantly (P<0.05).Conclusion Hemoperfusion can relief the condition of children with severe illness rapidly,and it’s mechanism may have relationship with adsorbing and removing a large number of inflammatory medium in the blood of the severe children.