CAJ | 학술논문

目的：观察自拟红黄抗氧化方对化疗期乳腺癌患者氧化应激相关血液指标、血液流变学指标,以及中医临床症状和应激症状的影响。方法将60例来自江苏省中医院乳腺病科的乳腺癌化疗期患者按单双数排序后随机分为治疗组与对照组,每组30例。治疗组在常规治疗基础上于化疗第1～14日服用中药红黄抗氧化方(每袋100 mL),每日2袋,早晚各1次；对照组常规治疗及化疗方案同治疗组。2组患者分别于化疗前1 d及化疗第4、7、14日测定血清中一氧化氮(NO)、超氧化物歧化酶(SOD)含量及血液流变学指标,同时评价患者中医症状积分及应激症状积分。结果化疗第4日,治疗组血清NO含量开始下降而SOD含量开始上升,但差异无统计学意义(P＞0.05)；化疗第7、14日,治疗组血清NO明显低于对照组,SOD含量明显高于对照组,差异有统计学意义(P＜0.05)。治疗组患者化疗第4日起,血液流变学指标较治疗前显著下降(P＜0.05),且明显优于对照组(P＜0.05)。化疗第4、7、14日,治疗组患者临床症状及应激症状积分较对照组均明显降低,差异有统计学意义(P＜0.05)。结论红黄抗氧化方可显著改善化疗期乳腺癌患者的氧化应激状态、相关的血清学指标及血流变学指标,改善临床症状。
목적：관찰자의홍황항양화방대화료기유선암환자양화응격상관혈액지표、혈액류변학지표,이급중의림상증상화응격증상적영향。방법장60례래자강소성중의원유선병과적유선암화료기환자안단쌍수배서후수궤분위치료조여대조조,매조30례。치료조재상규치료기출상우화료제1～14일복용중약홍황항양화방(매대100 mL),매일2대,조만각1차；대조조상규치료급화료방안동치료조。2조환자분별우화료전1 d급화료제4、7、14일측정혈청중일양화담(NO)、초양화물기화매(SOD)함량급혈액류변학지표,동시평개환자중의증상적분급응격증상적분。결과화료제4일,치료조혈청NO함량개시하강이SOD함량개시상승,단차이무통계학의의(P＞0.05)；화료제7、14일,치료조혈청NO명현저우대조조,SOD함량명현고우대조조,차이유통계학의의(P＜0.05)。치료조환자화료제4일기,혈액류변학지표교치료전현저하강(P＜0.05),차명현우우대조조(P＜0.05)。화료제4、7、14일,치료조환자림상증상급응격증상적분교대조조균명현강저,차이유통계학의의(P＜0.05)。결론홍황항양화방가현저개선화료기유선암환자적양화응격상태、상관적혈청학지표급혈류변학지표,개선림상증상。
ObjectiveTo observe the hong-huang antioxidant on oxidative stress in patients with breast cancer during chemotherapy, including their related blood indexes, blood rheology changes, and the effects on TCM clinical symptoms and symptoms of stress.MethodsA total of 60 cases of breast cancer patients during chemotherapy from Jiangsu Province Hospital of TCM was randomly divided into treatment group and control group, 30 cases in each group. On the basis of conventional therapy, patients in treatment group were given hong-huang antioxidant (100 mL per bag) from the 1st day to the 14th day of chemotherapy, 2 bags for each day (morning and evening). Patients in control group were given foundation treatment the same as the treatment group. Patients in the two groups had their serum NO, the content of SOD, and blood rheology tested on the day before chemotherapy, and the 4th, 7th, 14th days during chemotherapy. Meanwhile, their symptom score and the integral of stress reaction and TCM symptoms were also assessed. ResultsOn the 4th day, serum NO of treatment group decreased, while SOD content increased,without statistical significance between the two groups (P>0.05). Serum NO on the 7th, 14th days was significantly lower than that in the control group, but the content of SOD was higher than that in the control group, with statistical significance between the two groups (P<0.05). Hemorheology on the 4th day significantly decreased after treatment (P<0.05), and was significantly better than that in the control group (P<0.05); Clinical symptoms and stress symptoms integral in the treatment group were significantly lower than those in the control group on the 4th, 7th, 14th days of chemotherapy, with statistical significance (P<0.05).Conclusion Hong-huang antioxidant can significantly improve the oxidative stress status, serological indexes, related blood rheology indexes, and clinical symptoms in patients with breast cancer.