CAJ | 학술논문

目的：评价200 g/L小牛血去蛋白眼用凝胶治疗持续性角膜上皮缺损的临床疗效。 　　方法：观察持续性角膜上皮缺损患者168例(包括单疱病毒性角膜炎上皮型58例；化学烧伤24例；胬肉手术术后86例),随机分成小牛血去蛋白眼用凝胶组(84例),碱性成纤维细胞生长因子眼用凝胶组( bFGF,84例)。两组均滴眼4次/d,共7d。观察上皮缺损修复和患眼局部症状、体征等指标。 　　结果：小牛血去蛋白眼用凝胶组和bFGF组疗效判断指标较治疗前皆有显著性差异(P<0.01)。小牛血去蛋白眼用凝胶组有效率(83.3%)高于bFGF组(69%)；治疗单疱病毒性角膜炎上皮型角膜炎、化学烧伤和手术所引起的有效率分别为72.4%,69.2%和95.2%；观察过程中未见局部刺激和全身不良反应。 　　结论：小牛血去蛋白眼用凝胶治疗持续性角膜上皮缺损疗效确切,安全性高。
목적：평개200 g/L소우혈거단백안용응효치료지속성각막상피결손적림상료효。 　　방법：관찰지속성각막상피결손환자168례(포괄단포병독성각막염상피형58례；화학소상24례；노육수술술후86례),수궤분성소우혈거단백안용응효조(84례),감성성섬유세포생장인자안용응효조( bFGF,84례)。량조균적안4차/d,공7d。관찰상피결손수복화환안국부증상、체정등지표。 　　결과：소우혈거단백안용응효조화bFGF조료효판단지표교치료전개유현저성차이(P<0.01)。소우혈거단백안용응효조유효솔(83.3%)고우bFGF조(69%)；치료단포병독성각막염상피형각막염、화학소상화수술소인기적유효솔분별위72.4%,69.2%화95.2%；관찰과정중미견국부자격화전신불량반응。 　　결론：소우혈거단백안용응효치료지속성각막상피결손료효학절,안전성고。
AlM: To evaluate the clinical effect of 200g/L protein-free calf blood extract eye gel for corneal epithelial defect.METHODS: One hundred and sixty - eight cases of corneal epithelial defect ( 58 cases with herpes simplex keratitis; 24 cases with chemical injury; 85 cases with pterygium operation injury ) were randomly divided into two groups: 84 eyes were treated with protein-free calf blood extract eye gel; 84 cases were treated with basic fibroblast growth factor eye gel ( bFGF ) . The bFGF and protein-free calf blood extract eye gels were used 4 times a day. The treatment course was 7d. Epithelial defect restoration, local symptom and sign were observed. RESULTS: The difference between pre-treatment and post-treatment was significant ( P<0. 01 ) in the two groups. The effect of protein-free calf blood extract eye gel (83. 3%) group was prior to that of bFGF (69%) for corneal epithelial defect. The effective rate of protein-free calf blood extract eye gel in the herpes simplex keratitis, chemical injury and pterygium operation injury was 72. 4%,69. 2% and 95. 2%. Localized stimulus and adverse reaction of all over the body were not been observed. CONCLUSlON: Protein-free calf blood extract eye gels is valuable and safe for corneal epithelial defect.