CAJ | 학술논문

目的：分析强直性脊柱炎( AS)伴发前葡萄膜炎患者眼前段病变严重程度和炎性指标以及骶髂关节的影像学表现等相关因素的相互关系。 　　方法：回顾性分析55例AS伴前葡萄膜炎患者裂隙灯下眼前段病变情况与红细胞沉降率( ESR )、C 反应蛋白( CRP)以及骶髂关节的核磁共振表现。前葡萄膜炎严重程度根据EIU的临床标准改良,骶髂关节骨髓水肿的程度根据SPARCC的骶髂关节( SIJ)评分,分析二者之间的相互关系。 　　结果：AS患者55例中,EIU评分为2~10分,SPARCC评分为0~22分。进一步分析表明,葡萄膜炎评分与ESR (r=0.869,P<0.001)和CRP(r=0.485,P<0.001)均密切相关。强直性脊柱炎患者前葡萄膜炎严重程度与骶髂关节炎症程度不相关(r=0.237,P=0.081)。 　　结论：强直性脊柱炎患者前葡萄膜炎局部自身免疫炎症和骶髂关节的炎症及后续的骨化可能是各自独立的两个进程。
목적：분석강직성척주염( AS)반발전포도막염환자안전단병변엄중정도화염성지표이급저가관절적영상학표현등상관인소적상호관계。 　　방법：회고성분석55례AS반전포도막염환자렬극등하안전단병변정황여홍세포침강솔( ESR )、C 반응단백( CRP)이급저가관절적핵자공진표현。전포도막염엄중정도근거EIU적림상표준개량,저가관절골수수종적정도근거SPARCC적저가관절( SIJ)평분,분석이자지간적상호관계。 　　결과：AS환자55례중,EIU평분위2~10분,SPARCC평분위0~22분。진일보분석표명,포도막염평분여ESR (r=0.869,P<0.001)화CRP(r=0.485,P<0.001)균밀절상관。강직성척주염환자전포도막염엄중정도여저가관절염증정도불상관(r=0.237,P=0.081)。 　　결론：강직성척주염환자전포도막염국부자신면역염증화저가관절적염증급후속적골화가능시각자독립적량개진정。
AlM: To investigate the association between the degree of anterioruveitis and related factors including inflammatory markers as well as sacroiliac joint imaging in patients with ankylosing spondylitis ( AS) . METHODS: Anterior changes evaluated by slit lamp, erythrocyte sedimentation rate ( ESR ) , C - reactive protein ( CRP ) and magnetic resonance imaging of 55 cases with AS associateduveitis were retrospectively analyzed. A modified endotoxin-induced uveitis ( ElU ) clinical standard was used for uveitis grading. SPARCC sacroiliac scoring was used to evaluate bone edema of sacroiliac joint. The correlation between the degree of uveitis and sacroiliitis was assessed. RESULTS: ln the 55 patients with AS, ElU grading scored 2-10, and SPARCC index scored 0-22. Further analysis showed that the severity of uveitis was significantly correlated with ESR (r=0. 869, P<0. 001) and CRP (r=0. 485, P<0. 001). The degree of anterior uveitis in AS patients was not correlated with inflammation of sacroiliac joint (r=0. 237, P=0. 081). CONCLUSlON: Local autoimmunity of uveitis and sacroiliac joint inflammation with subsequent bone formation in AS might be mutually independent processes.