CAJ | 학술논문

目的：探讨 A 型肉毒毒素治疗中重度眼睑痉挛的临床疗效。 　　方法：选取本院眼科门诊诊断明确的眼睑痉挛的患者113例,采用A型肉毒毒素局部注射治疗,并对治疗疗效进行评估。 　　结果：患者59例(52.2%)症状完全缓解,49例(43.4%)明显改善,4例(3.5%)部分改善,1例无效(0.9%),总有效率达到99.1%。起效时间1~14d,大多于14d内达到最佳效果,疗效持续1~9 mo。不良反应可出现轻度眼睑闭合不全、上睑下垂、局部皮下瘀血等共23例,均在2~4 wk内恢复。 　　结论：局部注射A型肉毒毒素治疗中重度眼睑痉挛安全、有效。
목적：탐토 A 형육독독소치료중중도안검경련적림상료효。 　　방법：선취본원안과문진진단명학적안검경련적환자113례,채용A형육독독소국부주사치료,병대치료료효진행평고。 　　결과：환자59례(52.2%)증상완전완해,49례(43.4%)명현개선,4례(3.5%)부분개선,1례무효(0.9%),총유효솔체도99.1%。기효시간1~14d,대다우14d내체도최가효과,료효지속1~9 mo。불량반응가출현경도안검폐합불전、상검하수、국부피하어혈등공23례,균재2~4 wk내회복。 　　결론：국부주사A형육독독소치료중중도안검경련안전、유효。
AlM:To observe the efficacy of using botulinum toxin A in the treatment of blepharospasm. METHODS: Totally 113 patients with blepharospasm were managed with a local injection of botulinum toxin A, and the therapeutic effect was evaluated. RESULTS:Fifty-nine cases ( 52. 2%) had a complete remission of symptoms, 49 patients ( 43. 4%) presented with obvious relieved spasm, 4 cases ( 3. 5%) were partially relieved and the 1 patient ( 0. 9%) remained unchanged. The total effective rate was 99. 1%. The time of beginning effect was 1-14d. The recover time was mostly in 14d. The average of therapeutic effect lasted 1-9mo. Adverse reactions such as mild palpebra dysraphism, palpebra ptosis and local subcutaneous blood stasis were found in 23 patients, and the symptoms disappeared in 2-4wk. CONCLUSlON:Botulinum toxin A can effectively control medium and severe blepharospasm by injecting a little dose on local muscle.